A Study Evaluating 3-Level OLIF Spine Fusion

Inclusion Criteria * Male or female, 18-80 years of age * Patient must have degenerative disc disease, defined as discogenic back pain with degeneration of the disc confirmed by history and radiographic studies, affecting three contiguous levels between L2 and S1. Affected levels may also have up to Grade 1 spondylolisthesis or retrolisthesis * Patient must have at least 6 months on non-operative treatment prior to study enrollment * Patient signed Informed Consent Form * Patient signed HIPAA Authorization (may be part of the ICF) * Appropriate candidate for OLIF surgery using ViBone®, DBM, and BMP) * Patient will adhere to the scheduled follow-up visits and requirements of the protocol * Routine patient exams include pre-operative, operative, and three post-operative visits (3, 6, and 12 months post-surgery) * CT scan of surgical site 6 and 12 months post-surgery Exclusion Criteria * Long-term, chronic use of medications that are known to inhibit fusion, bone metabolism, or immune suppressants 6 months prior to surgery (i.e., steroids, chemotherapy, DMARDs, etc.) * Treatment with radiotherapy * Patients who have who have had surgery for primary tumors or metastatic malignant tumors of the lumbar or sacral spine * Nursing mothers or women who are pregnant or plan to become pregnant during the course of the study * Current or recent history of malignancy or infectious disease. Patients with current or recent history of basal cell carcinoma are eligible. * Inability to provide informed consent * Rapid joint disease, bone absorption, osteomalacia, and/or diagnosed osteoporosis (bone density test score of \<-2.5). * Other medical or surgical conditions which would preclude the potential benefit of surgery, such as congenital abnormalities, immunosuppressive disease, elevation of sedimentation rate unexplained by other diseases, elevation of white blood count (WBC), or marked left shift in the WBC differential count. * Morbid obesity as defined by a body mass index (BMI) of 40 or greater * Patients with an allergy to titanium or titanium alloy * Patients who are skeletally immature (\<18 years of age or no radiographic evidence of epiphyseal closure) * Active local or systemic infection or is undergoing adjunctive treatment for local or systemic infection. * Patients with a known hypersensitivity to recombinant Bone Morphogenetic Protein-2, bovine Type I collagen, or to other components of the formulation of the BMP