Single-Dose Study to Evaluate the PKs of Pretomanid in Participants With Renal Impairment Compared to Participants With Normal Renal Function

Inclusion Criteria: Participant Inclusion Criteria for Patients with Renal Impairment (Groups 2-4) 1. Have the ability to understand the requirements of the study and have provided written informed consent\* before any study-related procedure is performed. \*As evidence by signature on an informed consent document approved by the Institutional Review Board 2. Agree to abide by the study restrictions. 3. Are between the ages of 18 and 85 years, inclusive, at the time of enrollment. 4. Must have mild, moderate, or severe renal impairment or end stage renal disease (ESRD), but are not on dialysis. 5. Have no history of chronic tobacco/nicotine usage (i.e., \>10 cigarettes per day for 3 months minimum prior to admission). 6. Have corrected QT interval by Fridericia (QTcF) \<460 msec on Electrocardiogram (ECG). 7. Have a Body Mass Index (BMI) of 18 to 40 kg/m\^2 at enrollment. 8. Women of childbearing potential\*\* must use an acceptable contraception method\*\*\* for the duration of the study. \*\*Not sterilized via tubal ligation, bilateral oophorectomy, bilateral salpingectomy, hysterectomy, implanted contraceptive device placement (permanent, non-surgical, non-hormonal sterilization) with documented radiological confirmation test at least 90 days after the procedure, and still menstruating or \<1 year has passed since the last menses if menopausal. \*\*\*Includes, non-male sexual relationships, abstinence from sexual intercourse with a male partner, monogamous relationship with vasectomized partner who has been vasectomized for 180 days or more prior to the participant receiving study product, barrier methods such as condoms with spermicide or diaphragms/cervical caps with spermicide, effective intrauterine devices, NuvaRing(R), and licensed hormonal methods such as implants, injectables, or oral contraceptives ("the pill"). 9. If participant is male and capable of reproduction, agrees to avoid fathering a child for the duration of the study by using an acceptable method of birth control\*\*\*\*. \*\*\*\*In addition to the use of a barrier method (condom) unless vasectomized, acceptable methods of birth control are restricted to a monogamous relationship with a woman who agrees to use acceptable contraception as outlined in inclusion criterion #8, and/or abstinence from sexual intercourse with women. 10. Women of childbearing potential must have a negative urine pregnancy test within 24 hours prior to receipt of study product. Participant Inclusion Criteria for Healthy Participants (Groups 1A-1C) 1. Have the ability to understand the requirements of the study and have provided written informed consent\* before any study-related procedure is performed. \*As evidence by signature on an informed consent document approved by the Institutional Review Board (IRB). 2. Agree to abide by the study restrictions. 3. Are healthy male or non-pregnant female, between the ages of 18 and 85 years, inclusive, with normal GFR \>90 at screening. 4. Have no history of chronic tobacco/nicotine usage (i.e., \>10 cigarettes per day for 3 months minimum prior to admission). 5. Have a normal corrected QT interval by Fridericia (QTcF) \<460 msec on ECG. 6. Have a Body Mass Index of 18 to 40 kg/m\^2 at enrollment. 7. Women of childbearing potential\*\* must use an acceptable contraception method\*\*\* for the duration of the study. \*\*Not sterilized via tubal ligation, bilateral oophorectomy, bilateral salpingectomy, hysterectomy, implanted contraceptive device placement (permanent, non-surgical, non-hormonal sterilization) with documented radiological confirmation test at least 90 days after the procedure, and still menstruating or \<1 year has passed since the last menses if menopausal. \*\*\*Includes non-male sexual relationships, abstinence from sexual intercourse with a male partner, monogamous relationship with vasectomized partner who has been vasectomized for 180 days or more prior to the participant receiving study product, barrier methods such as condoms with spermicide or diaphragms/cervical caps with spermicide, effective intrauterine devices, NuvaRing(R), and licensed hormonal methods such as implants, injectables, or oral contraceptives ("the pill"). 8. If participant is male and capable of reproduction, agrees to avoid fathering a child for the duration of the study by using an acceptable method of birth control\*\*\*\*. \*\*\*\*In addition to the use of a barrier method (condom) unless vasectomized, acceptable methods of birth control are restricted to a monogamous relationship with a woman who agrees to use acceptable contraception as outlined in inclusion criterion #7, and/or abstinence from sexual intercourse with women. 9. Women of childbearing potential must have a negative urine pregnancy test within 24 hours prior to receipt of study product. Exclusion Criteria: Participant Exclusion Criteria for Patients with Renal Impairment (Groups 2-4) 1. History of known active TB. 2. History of peptic ulcer disease. 3. Known hypersensitivity to pretomanid or any of the excipients. 4. History of any clinically significant uncontrolled cardiac abnormality (as deemed by the Principal Investigator (PI)). 5. Any clinically significant electrocardiogram (ECG) abnormality at screening\*. \*Note: the following can be considered not clinically significant: \- Heart rate \</= 50 beats per minute (bpm) (sinus bradycardia with heart rate between 45 and 49, inclusive, is acceptable only in younger athletic participants, as determined by the Principal Investigator )) * Mild first-degree atrioventricular (A-V) block (P-R interval \>0.23 seconds) * Right or left axis deviation * Incomplete right bundle branch block * Isolated left anterior fascicular block (left anterior hemiblock) in younger athletic participants 6. History of, or screening results show a corrected QT interval by Fridericia (QTcF) \>/= 460 msec. 7. Family history of Long-QT Syndrome or sudden death when a cause of death is unknown. 8. Inability to swallow tablets. 9. History of fever or documented fever (oral temperature \>/= 100.4 degrees F) in the 48 hours prior to admission to the hospital. 10. Resting pulse rate \<50 or \>110 bpm at Screening. 11. At Screening, blood pressure \>/= 20 mm Hg systolic or \>10 mm Hg diastolic above baseline\*\* (sitting). \*\*Baseline is most recent blood pressure in the last 3 months. 12. Current hyperkalemia or hypomagnesemia. 13. Positive result of urine drug screen or blood alcohol screen prior to hospital admission except for approved prescriptions that are not opiates and benzodiazepines. 14. Significant history of drug and/or food allergies (as deemed by the Principal Investigator (PI)). 15. For women, participant is pregnant (positive test for urine Human Chorionic Gonadotropin \[HCG\]) at screening or Admission, breastfeeding, or planning to conceive for the duration of the study. 16. Any contraindication to the use of nitroimidazoles, or prior treatment with pretomanid or delamanid. 17. Treatment with strong or moderate CYP3A4 inducers or inhibitors\*\*\* within 14 days before admission and during the study\*\*\*\*. \*\*\*Except hormonal contraceptives \*\*\*\*In the opinion of the site investigator 18. Use of St. John's Wort within 7 days prior to admission and during the entire study. 19. Consumption of products containing grapefruit within 5 days prior to dosing until Visit 01N. 20. Donation of whole blood or blood products \>500 mL within 30 days from screening and/or plans to donate during the study or up to 14 days after dosing. 21. Participation in another interventional clinical trial within 30 days prior to dosing until after the last study visit. 22. Hemoglobin (Hgb) \<8.0 g/dL in both men and women at the screening visit. 23. Positive Screening test for Hepatitis C Virus (HCV), Hepatitis B Virus (HBV), or Human Immunodeficiency Virus (HIV). 24. Renal transplant. 25. Scheduled for hemodialysis or peritoneal dialysis. 26. Presence of any condition or finding\*\*\*\*\* which would jeopardize participant safety, impact study result validity, or diminish the participant's ability to undergo all study procedures and assessments. \*\*\*\*\*In the opinion of the investigator 27. For men, semen donation for the duration of the study. 28. Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) \> 2.5 x Upper Limit of Normal (ULN). 29. Hyperbilirubinemia \>1.5 x Upper Limits of Normal (ULN). Participant Exclusion Criteria for Healthy Participants (Groups 1A-1C) 1. History of known active TB. 2. History of peptic ulcer disease. 3. Known hypersensitivity to pretomanid or any of the excipients. 4. History of any clinically significant uncontrolled cardiac abnormality (as deemed by the Principal Investigator (PI)). 5. Any clinically significant ECG abnormality at screening.\* \*Note: the following can be considered not clinically significant: * Heart rate \</= 50 bpm (sinus bradycardia with heart rate between 45 and 49, inclusive, is acceptable only in younger athletic participants) * Mild first-degree A-V block (P-R interval \>0.23 seconds) * Right or left axis deviation * Incomplete right bundle branch block * Isolated left anterior fascicular block (left anterior hemiblock) in younger athletic participants 6. Family history of Long-QT Syndrome or sudden death when a cause of death is unknown. 7. Inability to swallow tablets. 8. History of fever or documented fever (oral temperature \>/= 100.4 degrees F) in the 48 hours prior to admission to the hospital. 9. At Screening blood pressure \>140/90 mm Hg or \<90/65 mm Hg (sitting). 10. History of, or screening results show a corrected QT interval by Fridericia (QTcF) \>460 msec. 11. Positive result of urine drug screen or blood alcohol screen prior to hospital admission except for approved prescriptions that are not opiates and benzodiazepines. 12. Significant history of drug and/or food allergies (as deemed by the Principal Investigator (PI)). 13. Women of childbearing potential with a positive urine pregnancy test within 24 hours prior to receipt of study product. 14. Any contraindication to the use of nitroimidazoles, or prior treatment with pretomanid or delamanid. 15. Treatment with strong or moderate CYP3A4 inducers or inhibitors\*\* within 14 days before admission and during the study\*\*\*. \*\*Except hormonal contraceptives \*\*\*In the opinion of the site Principal Investigator (PI) 16. Use of St. John's Wort within 7 days prior to admission and during the entire study. 17. Consumption of products containing grapefruit within 5 days prior to dosing until Visit 01N. 18. Donation of whole blood or blood products \>500 mL within 30 days from screening and/or plans to donate during the study or up to 14 days after dosing. 19. Participation in another interventional clinical trial within 30 days prior to dosing until after the last study visit. 20. Hgb \<10.0 g/dL in both men and women at the screening visit. 21. Positive Screening test for Hepatitis C virus (HCV), Hepatitis B virus (HBV), or Human Immunodeficiency Virus (HIV). 22. Renal transplant. 23. Presence of any condition or finding\*\*\*\* which would jeopardize participant safety, impact study result validity, or diminish the participant's ability to undergo all study procedures and assessments. \*\*\*\*In the opinion of the investigator 24. For men, semen donation for the duration of the study. 25. Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) \> Upper Limits of Normal (ULN). 26. Bilirubin \> Upper Limits of Normal (ULN)