Impulse Oscillometry for Prognostication in Idiopathic Pulmonary Fibrosis

University Hospital, Tours54 enrolled

Overview

A 5-point decline of forced vital capacity expressed as % predicted, over 6 months, is the current definition of disease progression (fast decline in lung function) in idiopathic pulmonary fibrosis. There is a need for techniques allowing to characterize disease progression earlier, so that treatment may be adapted as early as possible in the lack of a response. Hypothesis. Our hypothesis is that 3-month changes of lung function parameters measured by a novel technique, impulse oscillometry, predicts 6-month changes in forced vital capacity in idiopathic pulmonary fibrosis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Idiopathic Pulmonary Fibrosis

Interventions

Impulse OscillometryDIAGNOSTIC_TEST

Impulse Oscillometry will be performed in addition to usual care

Eligibility

Sex: ALLMin age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 45 years. * Idiopathic Pulmonary Fibrosis defined Interstitial Lung Diseases with 1) lack of any known cause for Interstitial Lung Diseases and 2) either the "definite usual interstitial pneumonia" pattern at CT scan, or the usual interstitial pneumonia (definite, probable or possible) pattern at lung biopsy, according to the Lung Function Group of the French Pulmonology Society criteria. Exclusion Criteria: * History of chronic obstructive airway disease. * History of congestive heart failure. * Emphysema-fibrosis syndrome, defined as emphysematous lesions involving \>15% of the lung area at the level of the aortic arch (upper lobes). * History of lower respiratory infection or acute respiratory failure of any cause less than 90 days before inclusion. * Opposition to data processing.

Locations (4)

Respiratory Functional Explorations, University Hospital, Lille

Lille, France

Respiratory Functional Explorations, University Hospital, Nantes

Nantes, France

Department of digestive physiology, urinary, respiratory and exercise, University Hospital, Rouen

Rouen, France

Pulmonology Department, University Hospital, Tours

Tours, France

Outcomes

Primary Outcomes

Performance of the 5-Hz reactance of the respiratory system (Xsr5) variation at 3 months, for the diagnosis of rapid decline in lung function.

Receiver operating characteristics curves will be used to determine diagnostic performance.