Fetal Ano-genital Distance in 2D Ultrasound.

University Hospital, Brest318 enrolled

Overview

The purpose of this study is to determine a threshold value of fetal anogenital distance in 2D ultrasound to differentiate male fetuses from female fetuses, starting 18 weeks of gestation and until the due date. The study also evaluates the feasibility of the measure and its interobserver variability.

The anogenital distance of female newborns is shorter than that of male newborns. Urogenital disorders, such as hypospadias and micro-penis, are associated with a shorter anogenital distance. Anogenital distance is a good marker of fetal exposure to androgenic substances. Prenatal anogenital distance ultrasound measure can help the diagnosis in case of doubt about fetal sexual phenotype or in case of urogenital disorder suspicion (hypospadias or micropenis). Is the anogenital distance easy to make measure? Can this procedure be reproduced? What are the threshold values to determine fetal sex at each term of pregnancy?

Study Type

OBSERVATIONAL

Enrollment

318

Conditions

Urogenital Abnormalities Prenatal Disorder Sex Development Disorder

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * pregnant woman * sonographic fetal follow up in Brest Hospital * term\>18 weeks of gestation Exclusion Criteria: * No datation between 11 weeks of gestation and 13 weeks of gestation and 6 days by crown-rump length measurement * Minor * no consent * ultrasound performed by an operator without ultrasonography graduation

Locations (1)

CHRU de Brest (Morvan)

Brest, France

Outcomes

Primary Outcomes

fetal anogenital distance

The distance will be measured from the center of the anus to the posterior convergence of the fourchette in female fetuses and to the posterior base of the scrotum in male fetuses