In this study we aim to investigate whether a 3-month life-style intervention would reduce oxidative stress (OS) in semen in men of infertile couples attending IVF-treatment. Men with a DFI above 15% (SCSA method) are recruited for intervention with a 3-month follow-up. It is hypothesized that men who also have a OS above 1.34 using a novel OS diagnostic method (MiOXSYS) respond better to antioxidant treatment with a change in OS and DFI. The primary outcome is the change in OS following the intervention. Secondary outcomes are morphological semen parameters and DNA fragmentation index.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
31
Omega 3: 1g daily for 3 months CoQ10: 100 mg daily for 3 months Multivitamin: 1 normal multivitamin tablet daily for 3 months
The Fertility Clinic Skive
Skive, Central Jutland, Denmark
Oxidative stress
Oxidative stress as measured with MiOxysis (Ayto Bioscience inc).
Time frame: 3 months
Semen quality
Morphological semen parameters using WHO recommendation for semen analysis.
Time frame: 3 months
DNA fragmentation index
DNA fragmentation index as measured by the method by SPZlab A/S (SCSA method)
Time frame: 3 months
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