Plasma TMAO (Trimethylamine N-oxide) as a Predictive Marker in Coronary Disease Patients

Gdansk University of Physical Education and Sport600 enrolled

Overview

The primary aim of the current research project is to determine whether the TMAO concentration in the blood can serve as a prognostic indicator of myocardial infarction. The hypothesis is that in patients with recent myocardial infarction, TMAO concentration in blood is higher than in patients undergoing scheduled coronarography.

To the study will be included volunteers - patients with stable angina (SA), who were scheduled for conventional coronary angiography, and patients with acute coronary syndrome (ACS) who were admitted to the hospital with chest pain and undergoing coronography surgery. Blood samples will be taken from volunteers once - before the coronography surgery by qualified medical personnel.

Study Type

OBSERVATIONAL

Enrollment

600

Conditions

Coronary Disease

Interventions

plasma samples collectionDIAGNOSTIC_TEST

Trimethylamine N-oxide (TMAO) concentration will be determined in plasma samples

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosed stable angina (SA) or acute coronary syndrome (ACS) and planned coronography Exclusion Criteria: * unconscious patient

Locations (1)

University of Physical Education and Sport

Gdansk, Pomeranian Voivodeship, Poland

Outcomes

Primary Outcomes

Trimethylamine-N-oxidec(TMAO) blood concentration

TMAO concentration determined by the ultra-performance liquid-chromatography tandem mass spektrometry (UPLC-MS/MS).

Time frame: Immediately before coronography.

Data from ClinicalTrials.gov

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