Neurophysiological Evaluation of Schizophrenia Patients After Cognitive and Physical Intervention

Aristotle University Of Thessaloniki4 enrolled

Overview

Neurophysilogical, neuropsychological evaluation and cognitive and physical training

24 sessions (8 weeks, 3 times per week) of cognitive and physical training via computer. Each session consisted of 45 minutes of cognitive traing (BrainHQ platform https://www.brainhq.com/) and 45 minutes of physical training (FitForAll platform https://www.fitforall.gr/play/app/). Cognitive training included memory, attention, velocity, intelligence etc. Physical training included aerobic, strength flexibility and other excercises. All evaluations were performed 1-14 before the initiation of the interventions and 1-14 after their completion. Neurophysiological evaluation consisted of EEG with the use of 128 electrode-machine and the protocol included 5 minuted of eyes closed and 5 minutes of eyes open. Neuropsychological evaluation included Trail Making Test (A \& B), Verbal Fluency, Stroop test, Wechsler Memory - Cubes (visuospatial), MoCA, FAB (Screening for frontal damage) and Eyes Test (Theory of Mind). Also, the physical condition evaluation included 6-Minute Walking Distance (6MWD), ΒΜΙ, HandGrip Strength Test, Short Physical Performance Battery Protocol.

Study Type

INTERVENTIONAL

Allocation

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Schizophrenia

Interventions

Cognitive TrainingOTHER

Cognitive training included memory, attention, velocity, intelligence

Physical TrainingOTHER

Physical training included aerobic, strength, flexibility and balance.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * a diagnosis of schizophrenia disorder according to ICD10 criteria * clinically stable patients (no recent change in psychotropic medication except benzodiazepines) * sufficient acculturation and fluency in Greek language * assent of the attending physician for participation in the study Exclusion Criteria: * co-morbidity with neurological disorders (e.g.epilepsy) or head injury * a pathological or other somatic disorder that contraindicate physical exercise * alcoholism and substance abuse within the previous 3 months (except caffeine and tobacco) * abstainance from intervention for more than 12 days * cognitive decline * treated with Benzodiazepine

Locations (1)

Laboratory of Medical Physics, AUTH

Thessaloniki, Greece

Outcomes

Primary Outcomes

Alterations in functional connectivity properties and on the organization of resting state networks

Alterations in functional connectivity properties and on the organization of resting state networks quantified through graph theory tools. These measures would be measured through high-density electroencephalographic (EEG) evaluation and reconstruction of cortical activity.

Time frame: 3 months

Secondary Outcomes

Physical fitness

Estimated through 6-Minute Walking Distance (6MWD)

Time frame: 2 months

Physical fitness

Estimated through ΒΜΙ

Time frame: 2 months

Physical fitness

Estimated through HandGrip Strength Test

Time frame: 2 months

Physical fitness

Estimated through Short Physical Performance Battery Protocol

Time frame: 2 months

Memory

Estimated through Wechsler Memory - Cubes (visuospatial) test

Time frame: 2 months

Executive function

Estimated through FAB (Frontalassesment test)

Time frame: 2 months

Depressive syndromes

Estimated through Had's test

Time frame: 2 months

Theory of mind

Data from ClinicalTrials.gov

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