Several drugs and chemotherapies seem to induce uveitis. This study investigates reports of uveitis, including the International classification of disease ICD-10 for treatments in the World Health Organization (WHO) global Individual Case Safety Report (ICSR) database (VigiBase).
Several drugs and chemotherapies seem to have an impact on the eyes and are responsible of uveitis. Those are poorly described, due to the modification of the pharmacopeia, and the recent recognition of several of these adverse events. This study investigates the main characteristics of patients affected by uveitis side effect imputed to drugs. A causality assessment according to the WHO-UMC (World Health Organization - Uppsala Monitoring Center) is systematically applied.
Study Type
OBSERVATIONAL
Enrollment
1,000
Drugs susceptible to induce uveitis
AP-HP, Pitié-Salpêtrière Hospital, Department of Pharmacology, CIC-1421, Pharmacovigilance Unit, INSERM
Paris, France
Eye toxicities of drugs Identification and report of cases of uevitis associated with drugs
Case reported in the World Health Organization (WHO) database of individual safety case reports
Time frame: to 01/04/2019
Causality assessment of reported uveitis according to the WHO system
Case reported in the World Health Organization (WHO) database of individual safety case reports
Time frame: to 01/04/2019
All relevants statisticals associations between type of uveitis and the category of drug
Case reported in the World Health Organization (WHO) database of individual safety case reports
Time frame: to 01/04/2019
All relevants statisticals associations between other concomittants immune related adverse events and uveitis induced by drugs
Case reported in the World Health Organization (WHO) database of individual safety case reports
Time frame: to 01/04/2019
Duration of treatment when uveitis happen (role of cumulative dose)
Case reported in the World Health Organization (WHO) database of individual safety case reports
Time frame: to 01/04/2019
All relevants statisticals associations between drug-drug interactions and adverse events
Case reported in the World Health Organization (WHO) database of individual safety case reports
Time frame: to 01/04/2019
All relevants statisticals associations between pathologies (cancer) for which the incriminated drugs have been prescribed, and occurence of uveitis
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Case reported in the World Health Organization (WHO) database of individual safety case reports
Time frame: to 01/04/2019
All relevants statisticals associations between characteristics of the population and occurence of uveitis adverse event
Case reported in the World Health Organization (WHO) database of individual safety case reports
Time frame: to 01/04/2019