Metabolic Effects of High-amylose Wheat-based Breads

Federico II University20 enrolled

Overview

The amylose-amylopectin ratio influences starch properties. A higher amylose content is associated with slower starch digestion thus reducing the postprandial plasma glucose response and improving the overall postprandial metabolism. So far, limited evidence is available on the metabolic effect of wheat-based foods rich in amylose. This randomised controlled study investigated the acute metabolic effects of amylose-rich wheat-based breads in overweight subjects focusing on potential mechanisms.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Postprandial Hyperglycemia

Interventions

Test mealOTHER

Participants received in random order the three test meal (700Kcal, 80g available carbohydrates) containing breads prepared with amylose-rich wheat flours (70% or 85%) or conventional flour. Blood samples were collected at fasting and every 30 minutes over 4 hours. Breath hydrogen was evaluated as a marker of intestinal fermentation. Participants underwent Visual Analogue Scale to assess subjective appetite sensations. After 4 hours, all participants consumed a standard lunch (700 kcal, 100 g available carbohydrates) identical on all the three experimental days to evaluate the "second meal effect" from breakfast to lunch.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Overweight/obese * 18-70 years Exclusion Criteria: * age \<18 and \>70 years; * fasting triglycerides ≥400 mg/dl; * fasting cholesterol \>270 mg/dl; * cardiovascular events (myocardial infarction or stroke) during the 6 months prior to the study * established diabetes mellitus or any chronic disease * renal and liver failure (creatinine \>1.7 mg/dl and transaminases \>2 times than normal values, respectively) * anaemia (Hb \<12 g /dl)

Locations (1)

Federico II University

Naples, Naples, Italy

Outcomes

Primary Outcomes

2-hours blood glucose response

incremental area under the curve

Time frame: over 2 hours after the test meal

Secondary Outcomes

2-hours blood insulin response

incremental area under the curve

Time frame: over 2 hours after the test meal

4-hours blood glucose response

incremental area under the curve

Time frame: over 4 hours after the test meal

4-hours blood insulin response

incremental area under the curve

Time frame: over 4 hours after the test meal

intestinal fermentation

breath test for the detection of hydrogen production

Time frame: over 4 hours after the test meal

glucose response

Second meal effect

Time frame: over 2 hours after the standard meal

Data from ClinicalTrials.gov

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