The best opioid for bronchoscopy is still unclear.This randomized double-blind prospective study was conducted on a total of 60 patients who were randomly allocated into 3 groups: Group S received sufentanil 0.1 mcg/kg, Group F received fentanyl 1 mcg/kg and Group R received remifentanil target-controlled infusion with effect-site target concentration of 1ng/ml. Patients in all groups received midazolam to achieve moderate levels of sedation as assessed by the Narcotrend (NT; between B1 and C2). Adverse events, patient tolerance and physician satisfaction were analized.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
60
Patients in Group S received sufentanil 0.1 mcg/kg.
Patients in Group F received fentanyl 1 mcg/kg.
Patients in Group R received remifentanil target-controlled infusion with effect-site target concentration of 1ng/ml.
Patients in all groups received midazolam to achieve moderate levels of sedation as assessed by the Narcotrend (NT; between B1 and C2).
the First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
Dosage of midazolam
Dosage of midazolam applied
Time frame: during the procedure
severity of cough
total times of cough
Time frame: during the procedure
patient's subjective tolerance
the intensity of four key symptoms during bronchoscopy (pain, nausea, breathlessness and cough) and memory using a visual analogic scale (VAS: 1 mm: excellent tolerance, 100 mm very low tolerance)
Time frame: 30minutes after bronchoscopy
patient's global tolerance assessed by operator
the global tolerance of patient to the procedure using a visual analogic scale (VAS: 1 mm: excellent tolerance, 100 mm very low tolerance)
Time frame: 30minutes after bronchoscopy
rate of oxygen desaturation
oxygen desaturation (SaO2 decrease\<90% for \>30 s)
Time frame: during the procedure
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