The Effects of Parenteral ω-3 Polyunsaturated Fatty Acid on Postoperative Complications of Patients With Crohn's Disease

Phase 4UnknownNCT03901937

Sir Run Run Shaw Hospital158 enrolled

Overview

This study is intended to investigate the safety and efficacy of ω-3 polyunsaturated fatty acid-based parenteral nutrition (PN) for patients with Crohn's disease.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

158

Conditions

Crohn Disease

Interventions

ω-3 polyunsaturated fatty acidDRUG

CD patients are divided into two groups, which include with and without ω-3 polyunsaturated fatty acid-based PN (0.1-0.2g/kg/d).

Intestinal surgery for Crohn's DiseasePROCEDURE

Patients receive bowel resection due to complications of Crohn's Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Diagnosis as Crohn's disease according to definition; 2. Bowel resection; 3. With parenteral nutrition at least 5 days 4. 18 years old\<age\<75 years old; 5. Sign the informed consent. Exclusion Criteria: 1. Emergency surgery; 2. With severe comorbidity and/or organ (kidney,liver,or heart) dysfunction; 3. Incomplete laboratory data; 4. With parenteral nutrition before surgery; 5. Pregnant; 6. Allergy of ω-3 polyunsaturated fatty acid.

Locations (1)

Sir Run Run Shaw hospital

Hangzhou, Zhejiang, China

RECRUITING

Outcomes

Primary Outcomes

Rate of Postoperative complications

postoperative complications after surgery for Crohn's Disease according to clavien-dindo system

Time frame: postoperative 1-30 days

Secondary Outcomes

Length of postoperative hospital stay

postoperative hospital stay after surgery for Crohn's Disease

Time frame: from surgery to discharge

Blood Concentration of IL-6

Blood Concentration of IL-6 after surgery