Effect of Prednisolone Treatment on Uterine Natural Killer Cells

Phase 3RecruitingNCT03902912

Chinese University of Hong Kong84 enrolled

Overview

This study aims to investigate the role of uNK cells and the association with prednisolone.

Glucocorticoids prednisolone is considered as a potential therapy in women with recurrent miscarriage. However, the evidence for treatment with prednisolone is still inconclusive and the relevant mechanism merits further investigations. The participants will be invited to take prednisolone oral 10 mg/day and attend our outpaitent clinic to be performed endometrial biopsy.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Recurrent Miscarriage

Interventions

PrednisoloneDRUG

prednisolone oral 10 mg/day from day one of the subsequent menstrual cycle to day LH 7 of that cycle. Then, the participants will be given a tailing off dose of 5 mg/day for 3 days followed by 2 mg/day for 3 days and then 1 mg/day for 3 days.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Women with a history of 3 or more consecutive miscarriages 2. Women younger than 40 years old Exclusion Criteria: 1. Allergy to prednisolone 2. Women who have any uterine anomaly 3. Antiphospholipid syndrome 4. Hydrosalpinx 5. Thrombophilia 6. Abnormal thyroid function tests 7. women with diabetes,

Locations (1)

The Chinese University of Hong Kong

Hong Kong, Hong Kong

RECRUITING

Outcomes

Primary Outcomes

the number of uNK cells

to investigate the association between uNK cells and prednisolone

Time frame: at the 1 day of endometrial biopsy

Central Contacts

Stacey Wong, BSc

CONTACT

85235051764 staceywong@cuhk.edu.hk

Pui Wah Jacqueline Chung, MBBS

CONTACT

85235051764 jacquelinechung@cuhk.edu.hk

Data from ClinicalTrials.gov

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