The Role of the Upper Colliculus in the Idiopathic Blepharospasm

University Hospital, Grenoble13 enrolled

Overview

This pilot study aims at investigating the role of superior colliculus in patients with idiopathic blepharospasm (BSP) de novo, compared to healthy subjects.

The objective of the study is to investigate the function of the superior colliculus (SC) related to visual stimulation by means of fMRI (functional magnetic resonance imaging) in patients with idiopathic BSP compared to healthy subjects. The hypothesis is that SC function is impaired in BSP (role of biomarker of SC).

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Blepharospasm, Benign Essential

Interventions

fMRIOTHER

bold signal in visual pathway

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Non treated idiopathic blepharospasm * Age: 30- 70 years Exclusion Criteria: * Under the following treatments: Botulin toxin, anticholinergic, benzodiazepines, baclofen, beta- and alpha-blockers collyrium * No MRI Contraindication

Locations (1)

CHU Grenoble Alpes

Grenoble, France

Outcomes

Primary Outcomes

Visual pathways fMRI

To measure the bold signal in superior colliculus and lateral geniculate corpus

Time frame: In a five months period after inclusion

Data from ClinicalTrials.gov

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