Serum LncRNAs as Early Potential Biomarkers for the Prediction of Preeclampsia

First Affiliated Hospital of Harbin Medical University260 enrolled

Overview

To identify lncRNAs differentially expressed at early stages of gestation in the serum of pregnant women, who later developed severe preeclampsia (sPE) in the third trimester of pregnancy compared to women with normal pregnancy .

Preeclampsia (PE) is a pregnancy syndrome characterized by hypertension and proteinuria, and a leading cause of maternal and fetal morbidity and mortality, with poorly defined pathophysiological mechanisms remain. Circulating lncRNAs are long, noncoding RNA molecules, which negatively regulate gene expression, and considered as promising biomarkers for PE. The objective of the study is to evaluate circulating lncRNA signatures in women with PE compared to healthy women, and in women sub-grouped per PE severity. This study assessed lncRNA expression profile in the serum at early stages of gestation of women who later developed severe preeclampsia (sPE) in the third trimester of pregnancy compared to women with uncomplicated pregnancies. Circulating lncRNA was extracted from maternal serum. This study also assess lncRNA expression profile in the placenta tissues of PE patients and healthy pregnant women.

Study Type

OBSERVATIONAL

Enrollment

260

Conditions

Preeclampsia

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * new onset hypertension (systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg on two occasions at least 4 h apart) after 20 weeks of gestation in women who previously had normal blood pressure. * proteinuria (the excretion of 300 mg or more of protein in a 24-hour urine collection)or other signs/symptoms of preeclampsia after 20 weeks of gestation in women who previously had normal blood pressure. Exclusion Criteria: * maternal infections * smoking * chemical dependency * known major foetal or chromosomal anomalies * intrahepatic cholestasis during pregnancy * assisted reproductive technology (ART) treatments * chronic hypertension.

Locations (1)

Serum LncRNAs as Potential Biomarkers for the Prediction of Preeclampsia

Harbin, Heilongjiang, China

RECRUITING

Outcomes

Primary Outcomes

The RNA expression levels of lncRNAs

the serum of patients with preeclampsia and in the serum of normal controls were measured by qRT-PCR.

Time frame: 5 months

Central Contacts

Yue Li, MD

CONTACT

86-451-85555673 ly99ly@vip.163.com

Data from ClinicalTrials.gov

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