Anomalies of Nocturnal Gaz Exchanges in Patients With Down Syndrome

Institut Jerome Lejeune48 enrolled

Overview

Recently, retrospective studies have shown that Down Syndrome children have a higher CO2 (carbone dioxide) sleep pressure than the general pediatric population. This increase does not seem to be always related to sleep apnea. The Investigators wish to confirm these results prospectively. The investigators hypothesize that this alveolar hypoventilation may be due to ventilatory control disorders caused by dysautonomia, but also to a decrease in the strength of the respiratory muscles within the framework of the global muscular hypotonia described in children with Down syndrome. .

47 Down syndrome patients age from 4 to 16 will be included. They will perform a medical visit at J0, then a measurement of gaz nocturnal exchanges at home within 1 month

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Down Syndrome

Interventions

Nocturnal gaz exchanges measurementOTHER

Nocturnal gaz exchanges at patient's home BRIEF neuropsychological questionnaire VINELAND-II neuropsychological questionnaire Clinical OSA assessment Dysautonomia assessment

Eligibility

Sex: ALLMin age: 4 YearsMax age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Down syndrome patient without mosaicism * Age 4 to 16 years * Predominant French language in the living environment Exclusion Criteria: * OAS diagnostic focused on an earlier polysomnography * Methylphenidate treatment started before inclusion

Locations (1)

Hôpital Armand Trousseau

Paris, France

Outcomes

Primary Outcomes

Number of patients with high mean PtcCO2 as assessed by nocturnal gas exchange recordings

Time frame: 2 months

Secondary Outcomes

Percentage of total sleep time with a PtcCO2 in mmHg higher than 50; mean, maximum and minimum SpO2 in %

Time frame: 2 months

Number of patients with low mean, minimum and maximum SpO2 (oyxygen saturation) and/or % of Total sleep time spent with a PtcCO2 higher than 50 mmHg, higher than 20%, as measured by nocturnal gas exchange recordings.

Time frame: 2 months

Correlation between nocturnal PtcCO2 value and the existence of executive function and behavioral disorders assed by the Dysautonomia questionnaire

Time frame: 2 months

Correlation between nocturnal PtcCO2 value and the existence of executive function and behavioral disorders measured by Hand Grip assessment

Time frame: 2 months

Correlation between nocturnal PtcCO2 value and the existence of executive function and behavioral disorders measured by OSA (Obstructive Sleep Apnea) assessment questionnaire

Time frame: 2 months

Data from ClinicalTrials.gov

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