Tegio Consolidation Therapy for NPC Patients With High Risk of Metastasis

Inclusion Criteria: 1. Age 18-70 ys 2. Performance status of Eastern Cooperative Oncology Group (ECOG) grade 0 -2 3. Tumor staged as 8th American Joint Committee on Cance (AJCC) T3-4N2M0 or T1-4N3M0 with histologically confirmed 4. Within 12weeks after completion of the curative radiotherapy treatment 5. disease was controlled after radiotherapy 6. with adequate hematologic (neutrophil count \> 1.5×10\^9/L, hemoglobin \> 90g/L and platelet count \> 100×10\^9/L), hepatic (alanine aminotransferase, aspartate aminotransferase ≤ 1.5×ULN, bilirubin ≤ 1.5×ULN, alkaline phosphatase \< 2.5×ULN) and renal function (creatinine clearance \> 50 ml/min) 7. Patients must be informed and written informed consent was finished. Exclusion Criteria: 1. allergic to Tegio. 2. Illness may interfere with oral medication, including dysphagia, chronic diarrhea, or ileus 3. Prior malignancy except treated basal cell or in situ cervical cancer. 4. Pregnancy or lactation (consider pregnancy test in women of child-bearing age and emphasize effective contraception during the treatment period). 5. severe comorbidities may bring unacceptable risk or affect the compliance of the trial, including but not limited to unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control (fasting plasma glucose \> 1.5×ULN), and emotional disturbance.