Assessment of Myocardial Injury in Simultaneous Pancreas and Kidney Transplantation

Tianjin First Central Hospital50 enrolled

Overview

Diabetic cardiomyopathy( DCM) is a major complication of diabetes and is a common cardiovascular complication independent of coronary artery disease and hypertension．Trial to assess of myocardial injury in recipients of simultaneous pancreas and kidney transplantation by nuclear magnetic T２ mapping technology.

1. Evaluate the changes of myocardial injury before and after SPK by cardiac magnetic resonance imaging (CMR), 2. Evaluate the value of SPK in the repair of myocardial injury by comparing with the single renal transplant in recipients with diabetic nephropathy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Simultaneous Pancreas-kidney Transplantation Diabetic Cardiomyopathy

Interventions

cardiac magnetic resonance(CMR) T2 mappingRADIATION

T2 value before transplant，3 month and 6month after transplant

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. patients with type 2 diabetes were treated with SPK; 2.No definite history of cardiovascular diseases (such as congenital heart disease, coronary heart disease, cardiomyopathy or valvular heart disease, etc.); 3. Preoperative hemodialysis 4. No history of heart failure Exclusion Criteria: 1. Contraindications in cardiac magnetic resonance imaging；2.poorly controlled hypertension；3.CMR examination revealed marked hypertrophy of the left ventricular myocardium

Locations (1)

Tianjin First central hospital

Tianjin, China

Outcomes

Primary Outcomes

Assessment of myocardial injury

Assessment of myocardial injury between two groups

Time frame: 1year

Data from ClinicalTrials.gov

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