Geriatric Recovery Using Inpatient and Post-hospitalization Supplementation

The University of Texas Medical Branch, Galveston116 enrolled

Overview

The purpose of the study is to determine the feasibility of nutritional interventions designed to help older patients maintain physical function after being in the hospital. We will test the feasibility and effect of nutritional interventions with whey protein, collagen or placebo on functional recovery from hospitalization in community dwelling older adults.

We will compare in a randomized parallel design double blind pilot phase I study the feasibility of whey protein vs. collagen vs. isocaloric placebo supplementation in older adults during an acute hospitalization for a medical condition, and the treatments' effect size on physical function after hospital discharge.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

116

Conditions

Aging

Interventions

Whey ProteinDIETARY_SUPPLEMENT

30 g of whey protein in flavored water, twice daily, during hospitalization and for 30 days post-discharge

Collagen ProteinDIETARY_SUPPLEMENT

30 g of collagen protein in flavored water, twice daily, during hospitalization and for 30 days post-discharge

PlaceboDIETARY_SUPPLEMENT

30 g of maltodextrin in flavored water, twice daily, during hospitalization and for 30 days post-discharge

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 65 years or older. * Admitted to UTMB hospital for any acute medical condition * English speaking Exclusion Criteria: * Inability to consent * Bed or wheelchair bound prior to hospitalization * Estimated creatinine clearance 20 ml/min or less, or end stage renal disease not on dialysis * AST/ALT 2.5 times above the normal limit * Active cancer * Palliative care/Hospice * Estimated protein intake \>1.2 g/kg/day during the previous 24 hours * Any other condition or event considered exclusionary by the PI and faculty physician

Locations (2)

UTMB Acute Care for Elders Unit

Galveston, Texas, United States

Jennie Sealy Hospital

Galveston, Texas, United States

Outcomes

Primary Outcomes

Physical Function

Short Physical Performance Battery (SPPB) scale, 0-12 points. 0=disabled; 12=high performance

Time frame: Change from baseline to 30 days after discharge

Data from ClinicalTrials.gov

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