Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning in Patients With Type 1 Diabetes

University of Aarhus21 enrolled

Overview

Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury. It remains unknown whether this can be used in retinal ischemic diseases. The purpose of the present study is to examine if the autoregulation of retinal vessel diameters in diabetic patients change after remote ischemic conditioning and if the observations are different from what have been observed in normal persons.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Retinal Ischemia Diabetes Complications Ischemia Diabetes Mellitus, Type 1

Interventions

Remote Ischemic ConditioningOTHER

Brief reversible restriction of blood flow to upper limb in four cycles of 5 minutes of inflation at 200mm Hg followed by 5 minutes of deflation.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 31 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diabetes type 1 * Diabetic retinopathy Exclusion Criteria: * Previous treatment for diabetic retinopathy * Other ocular and systemic diseases requiring treatment * Pregnancy or lactation

Locations (1)

University of Aarhus

Aarhus C, Danmark, Denmark

Outcomes

Primary Outcomes

Diameter change of retinal vessels

Diameter change from baseline in percent.

Time frame: Immediately after and one hour after

Data from ClinicalTrials.gov

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