Study on OMT-28 in Maintenance of Sinus Rhythm in Patients With Persistent Atrial Fibrillation (AF)

Inclusion Criteria: * Males or females between 18 and 85 years of age. * Patients with persistent AF for \> 7 days but ≤ 3 months suitable for electrical DCC. * Male patients must be surgically sterile for at least 90 days or will be required to use a male condom with spermicide, and will refrain from donating sperm from the time of the first dose until 90 days after the last dose of study medication. * Females of childbearing potential (postmenarchal, not surgically sterile, premenopausal) will agree to follow contraception requirements from the time of signing the Informed Consent Form (ICF) until 90 days after the last administration of study drug. * Willing and able to give written informed consent before any study-related procedure. * Willing and able to attend all the visits scheduled in the study. Main Exclusion Criteria: * Patients with known concurrent temporary secondary causes of AF * Patients that have undergone surgical or catheter ablation for AF or atrial flutter. * Patients with an existing cardiac treatment device, pacemaker, implantable cardioverter defibrillator, or cardiac resynchronization therapy. * Patients with a history of ECG abnormalities that, in the opinion of the investigator (or designee), render the patient unsuitable for the study. * Patients with congestive heart failure (NYHA class III and IV). * Patients with left atrium size ≥ 55 mm. * Patients with left ventricular ejection fraction ≤ 40 %. * Known presence of a thrombus in the left atrial appendage, left atrium, left ventricle, aorta, or intracardial mass. * Patients with moderate or severe mitral stenosis, mitral valve rheumatic disease, unresected atrial myxoma, or a mechanical heart valve and/or other conditions, such as pulmonary embolism, considered to be formal indication for conventional anticoagulation. * Patients with any acute coronary event, stroke, or percutaneous coronary intervention within 6 months prior to randomization or who are receiving dual antiplatelet therapy. * Uncontrolled/therapy-resistant bradycardia and/or uncontrolled/therapy-resistant hypertension within a 3-month period prior to randomization. * Patients having more than two DCCs in the last 6 months. Any unsuccessful pharmacological and/or electrical cardioversion (within prior 3 months). * Patients with signs of bleeding or conditions associated with a high risk of bleeding. * Patients taking antiarrhythmic agents within 3 days of planned randomization will be excluded. * Patients concurrently participating in another study or unable to communicate. * Patients with active cancer, chronic kidney disease or intercurrent illness. * Pregnant or breastfeeding women. * Patients taking concomitant medication.