To study the pathological mechanism of cataract by genomics, transcriptomics, and proteomics.
Tissue samples and aqueous humor samples will be collected from each individual patients by cataract surgery. After sample treatment, different techniques will be applied for analysis. And bioinformatics approach is applied for data treatment and analysis.The data of genomics, transcriptomics, and proteomics will be analyzed for study of pathological mechanism of cataract.
Study Type
OBSERVATIONAL
Enrollment
20
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University
Shanghai, China
RECRUITINGCharacterization of miRNA in micro-scale human aqueous humor
method development for miRNA detection in aqueous humor
Time frame: 12 month
Favored amplification recovery via protection-chromatin immunoprecipitation-Seq of human eye tissue samples
low-cell-number epigenome profiling for study of cataract
Time frame: 24 month
Study of cataract by genomics, transcriptomics, and proteomics approaches
detect histone H3 lysine 4 trimethylation (H3K4me3) of aqueous humor of cataract patients by genomics, transcriptomics, and proteomics methods
Time frame: 36 month
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