Chronic widespread pain (CWP), defined as long-lasting pain in multiple body regions, has a prevalence of 10-14% in Europe and is associated with other physical symptoms such as fatigue and cognitive problems. Individuals with longstanding pain also have a high prevalence of sleep disturbances, and sleep problems can in itself lead to tiredness, lower neurocognitive function and higher pain ratings. However, studies of comorbid sleep problems for individuals with CWP are a lacking, and the primary aim for the present study is to assess the prevalence of sleep disturbances in individuals with CWP, and to see how this covariates with pain, fatigue, activity level, neurocognitive functioning, and biomarkers. As a secondary aim the study will assess a subgroup of the individuals, that has received multimodal pain management treatment, a second time after 6 months to analyze how the prevalence of sleep disturbances and other associated problems covaries over time.
Study Type
OBSERVATIONAL
Enrollment
96
Sleep screening, neurocognitive assessment, activity monitoring questionnaires, blood sample
Uppsala university hospital
Uppsala, Uppsala County, Sweden
Polysomnography
Assessment of objective sleep problems
Time frame: 6 months
CANTAB
Neurocognitive screening
Time frame: 6 months
Actigraph
Activity level
Time frame: 6 months
Biomarkers
92-plex inflammatory panel
Time frame: 6 months
Pain level
The Brief Pain Inventory - Short Form, BPI, a 9 item (0-10) self-administered questionnaire, assessing the severity of a patient's pain and the impact of this pain on the patient's daily functioning. Maximum total score possible is 90. Higher the score, greater the degree of disability.
Time frame: 6 months
Fatigue
Fatigue severity scale, FSS, a 9 item self-administered questionnaire assessing severity of fatigue and how fatigue interferes with activity. Items are scored on a 7 point scale, minimum total score possible is 9 and maximum 63. Higher the score, greater the severity.
Time frame: 6 months
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