Assessing Best Medical Treatment Patterns of Patients With Symptomatic Peripheral Arterial Occlusive Disease in Germany

Universitätsklinikum Hamburg-Eppendorf60,000 enrolled

Overview

This proposed study will be conducted to support real-world-evidence on the extent of best medical treatment for secondary prevention of patients with symptomatic peripheral arterial occlusive disease (PAOD) for prevention of worsening limb symptoms or of major adverse cardiovascular events. The overall objective of this study is to gain a better understanding of patient characteristics, treatment patterns and outcomes in PAOD patients. For this purpose the investigators will analyze a patient population hospitalized either with intermittent claudication (IC) or chronic limb-threatening ischaemia (CLTI) while taking prior PAOD-related diagnoses in the outpatient setting into account. In detail, we study differentials according to age, calendar time, sex, disease severity and hospital procedure. Data were extracted from available German health insurance claims.

Study Type

OBSERVATIONAL

Enrollment

60,000

Conditions

Peripheral Artery Disease Intermittent Claudication Critical Limb Ischemia

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

1. First clinical diagnosis of symptomatic peripheral arterial occlusive disease (according to Fontaine classification, stages II, III and IV) after at least 5 years without such clinical diagnosis 2. At least 18 years of age Exclusion Criteria: 3. Incomplete information on sex, age, date of hospital discharge 4. Less than 5 years of insurance membership before index stay

Outcomes

Primary Outcomes

Number of participants receiving best-medical-treatment

Prevalence of the outpatient prescription of best medical treatment defined as picking up a medication at a pharmacy for a lipid-lowering, an antithrombotic, and an antihypertensive drug agent, within 12 months after index discharge for POAD according to information provided in health insurance claims data

Time frame: at 12 months after discharge

Secondary Outcomes

Number of participants deceased

Rate of all-cause mortality after index discharge for POAD according to information provided in health insurance claims