Pomalidomide for the Treatment of Bleeding in HHT

Inclusion Criteria: 1. A clinical diagnosis of HHT as defined by the Curacao criteria 2. Age ≥ 18 years 3. Platelet count ≥ 100,000/µl 4. White Blood Count (WBC) ≥ 2,500/µl 5. International Normalized Ratio (INR) ≤ 1.4 and normal ± 2 sec activated partial thromboplastin time (aPTT or partial thromboplastin time (PTT) per local laboratory designation) by local laboratory criteria (except for patients on a stable dose of warfarin or direct oral anticoagulants) 6. Epistaxis severity score ≥ 3 measured over the preceding three months, measured at the screening visit 7. A requirement for anemia, as determined by local laboratory hemoglobin assessment and normal ranges, and/or parenteral infusion of at least 250 mg of iron or transfusion of 1 unit of blood over the 24 weeks preceding the screening visit 8. All study participants must agree to be registered into the FDA mandated POMALYST Risk Evaluation and Mitigation Strategy (REMS) program, and be willing and able to comply with the requirements of the POMALYST REMS program 9. Females of childbearing potential (FCBP) must adhere to the scheduled pregnancy testing as required in the POMALYST REMS program. FCBP must have a negative pregnancy test with a sensitivity of at least 50 milli-international units per milliliter (mIU/mL) within 10 - 14 days prior to and again within 24 hours prior to prescribing pomalidomide and must either commit to continued abstinence from heterosexual intercourse or use two (2) acceptable methods of birth control, one highly effective method and one additional effective method at the same time, at least 28 days before she starts taking pomalidomide, during therapy and for at least 4 weeks following discontinuation of therapy. Men must agree to use a latex condom during sexual contact with a FCBP even if they have had a vasectomy. 10. Ability to understand and sign informed consent Exclusion Criteria: 1. Women currently breast feeding 2. Renal insufficiency, serum creatinine \> 2.0 mg/dl 3. Hepatic insufficiency, bilirubin \> 2.0 (or \>4.0 in the setting of a prior clinical or genetic diagnosis of Gilbert's syndrome) or transaminases \> 3.0x normal 4. Prior treatment with thalidomide or other Immunomodulatory imide drugs within previous 6 months 5. Prior treatment with bevacizumab (systemic or nasal) within previous 6 weeks\* 6. Prior treatment with pazopanib within previous 6 weeks\* 7. The use of octreotide or oral estrogens within the previous month\* 8. History of prior unprovoked thromboembolism confirmed by venous ultrasound or other imaging modalities 9. Peripheral neuropathy, confirmed by neurologic consultation 10. Known underlying hypoproliferative anemia (i.e. myelodysplasia, aplastic anemia) 11. Currently enrolled in other interventional trials 12. Known hypersensitivity to thalidomide or lenalidomide. 13. The development of erythema nodosum if characterized by a desquamating rash while taking thalidomide or similar drugs. 14. Known SMAD Family Member 4 (SMAD-4) mutation, unless there has been a colonoscopy with normal (negative) results, or in which the patient has had no more than 5 small (in the opinion of the gastroenterologist) colonic polyps completely removed within the preceding 18 months 15. Anything that in the investigator's opinion is likely to interfere with completion of the study * \* Use of these treatments is not permitted during study participation.