The Effect of a Probiotic Strain on Aspirin-induced GI Damage

Inclusion Criteria: * Written informed consent * Healthy and without any gastrointestinal discomfort/pain symptoms * Age 40-60 years of both genders (aim of minimum 1/3 of each gender in each arm) * Willing and able to abstain from any other probiotic products and/or medication known to alter gastrointestinal function throughout the participation of the trial Exclusion Criteria: * Abdominal surgery which, as judged by the investigator, might affect the GI function (except appendectomy and cholecystectomy) * History of peptic ulcer disease * Any known bleeding disorder * Allergy to ASA * Resting diastolic blood pressure ≥ 95 mmHg * Resting systolic blood pressure ≥ 150 mmHg * A current diagnosis of psychiatric disease * Systemic use of antibiotics, steroids (except contraceptives) or antimicrobial medication in the last 2 months * Daily usage of non-steroidal anti-inflammatory drugs in the last 2 months or incidental use in the last 2 weeks prior to screening (ASA, Ibuprofen, Diclofenac, Naproxen, Celecoxib, Mefenamic acid, Etoricoxib, Indometacin) * Usage of medications, except contraceptives, in the last 2 weeks prior to screening * Diagnosed inflammatory gastrointestinal disease and/or irritable bowel syndrome * Any other disease that, by the Investigators discretion, could interfere with the intestinal barrier function of the subject * Participation in other clinical trials in the past 2 months prior to screening * Regular use of probiotics in the last month * Smoking and/or frequent use of other nicotine products * Desire and/or plans on changing current diet and/or exercise regime during the participation of this trial * Use of laxatives, anti-diarrheals, anti-cholinergics and proton pump inhibitors within last 2 months prior to screening * Use of immunosuppressant drugs within last 4 weeks prior to screening * For Women: Pregnancy or lactation