Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare

Inclusion Criteria: * 18 years old or older * Diagnosis of cutaneous sarcoidosis or granuloma annulare with supportive skin biopsies in which other causes of granulomas (infectious, foreign body) have been ruled out * Patients with either: Cutaneous Sarcoidosis Activity and Morphology (CSAMI) activity score greater than or equal to 10 (patients with a CSAMI greater than or equal to 10 have active cutaneous sarcoidosis involving several distinct cutaneous sites and would otherwise be considered candidates for systemic therapy), or any CSAMI score and sarcoidosis involvement causing functional impairment (i.e. nasal or visual field obstruction). * For patients with granuloma annulare, patients with 5% or greater Body Surface Area (BSA) will be enrolled. * If patients are on other systemic therapies for their sarcoidosis or granuloma annulare, they must be taking a stable dose of the other medication(s) for at least 3 months with no plans to change the regimen in the next 6 months. With the exception of methotrexate and/or low dose prednisone, use of concomitant immunosuppressants, e.g. infliximab, azathioprine, etc., will not be permitted. * Females of childbearing potential must agree to use birth control during the study and there must be a negative pregnancy test documented prior to starting the medication. * Patients must be willing to undergo skin biopsies, blood collection, and total body photography and comply with clinic visits Exclusion Criteria: * Age \<18 years old * Patients with a history of malignancy (except history of successfully treated basal cell or squamous cell carcinoma of the skin) * Patients known to be HIV or hepatitis B (HBV) or C (HCV) positive (prior exposure to but clearance of HBV and HCV is acceptable for study entry as long as patient is being monitored by hepatology) * Patients with active tuberculosis or untreated latent tuberculosis as determined by positive tuberculin skin test or positive QuantiFERON® Tuberculosis (TB) test and, as necessary, chest X-ray * Patients with significant hepatic impairment * Patients with untreated peptic ulcer disease * Patients taking immunosuppressive medications, with the exception of methotrexate and/or low- dose prednisone, including but not limited to mycophenolate mofetil, azathioprine, tacrolimus, cyclosporine, or Tumor Necrosis Factor (TNF-α) inhibitors * Women of childbearing potential who are unable or unwilling to use birth control while taking the medication * Women who are pregnant or nursing. If a woman becomes pregnant during the study, she will stop study medication and be removed from the study. She will be urged to follow up with her Primary Care Physician or OB/GYN. The study doctors will ask to follow the pregnancy to its outcome.