The Improvement of Intraoperative Neuromonitoring of Recurrent Laryngeal Nerve

Kaohsiung Medical University Chung-Ho Memorial Hospital60 enrolled

Overview

Objectives: The use of neuromuscular blocking agent may interfere with the function of intraoperative neuromonitoring (IONM) in thyroid surgery.

An enhanced neuromuscular-blockade (NMB) recovery protocol was investigated in a clinically applied during thyroid neural monitoring surgery. In as subsequent clinical application study, 60 patients who underwent thyroidectomy with IONM followed an enhanced NMB recovery protocol- rocuronium 0.6 mg/kg at anesthesia induction and sugammadex 2 mg/kg at operation start. Train-of-four (TOF) ratio was used for continuous quantitative monitoring of neuromuscular transmission.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Thyroid Intra-Operative Injury

Interventions

sugammadexDRUG

standard general anesthesia protocol with sugammadex

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy Exclusion Criteria: * Patients with a history of significant cardiac, pulmonary, hepatic, or renal disease, body mass index \<18.5 or \>35, chronic drug or alcohol abuse

Locations (1)

I-Cheng Lu

Kaohsiung City, Taiwan

Outcomes

Primary Outcomes

sugammadex 2 mg/kg allows effective and rapid restoration of neuromuscular function suppressed by rocuronium

Electromyography signal to assess the quality of neuromonitoring

Time frame: 1 month each case

Data from ClinicalTrials.gov

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