Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study

Inclusion Criteria: * Male or Female ≥ 17 (or the provincial age of majority - depending on local REB guidelines) * Complete (AIS A) or incomplete (AIS B, C) acute traumatic spinal cord injury. * Bony spinal levels between C0 and T12 inclusive. * Blunt (non-penetrating) spinal cord injury treated either surgically or non-surgically * Lumbar intrathecal catheter to be inserted as part of clinical hemodynamic management and CSF sample collected within 48 hours of injury * Initial blood sample collected within 24 hours of injury Exclusion Criteria: * Motor incomplete spinal cord injury AIS D (i.e. at least half (half or more) of the key muscle functions below the neurological level of injury (NLI) have a muscle grade greater than or equal to 3/5) * Spinal cord injury with sensory deficit only (i.e. no motor deficit) * Penetrating spinal cord injury (including gunshot wounds) * Isolated radiculopathy * Isolated cauda equina injury or spinal injury below L1 * Associated injury (soft tissue or bony) to the lumbar spine where the intrathecal catheter would be placed * Associated traumatic conditions that would interfere with the outcome assessment (e.g., traumatic brain injury, chest, pelvis, abdomen, or femur injury requiring operative intervention) * Pre-existing neurodegenerative disorder, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis * Pre-existing thromboembolic disease or coagulopathy, such as hemophilia, von Willebrand disease * Presence of systemic disease that might interfere with patient safety, compliance or evaluation of the condition under study (e.g., clinically significant cardiac disease, HIV, Hep B or C) HTLV-1 * Pre-existing inflammatory or autoimmune disorder (e.g. rheumatoid arthritis, systemic lupus, psoriasis, or ankylosing spondylitis * Any other medical condition that in the investigator's opinion would render the protocol procedures dangerous or impair the ability of the patient to receive protocol therapy * Female patients who are pregnant