The main purposes of this study are: 1. To learn more about the safety and side effects of different formulations of LY3375880 and 2. To measure how much LY3375880 gets into the blood stream and how long it takes to get out of the body. The study will last about 85 days. Screening may occur up to 28 days prior to enrollment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
83
Administered SC
Administered SC
AI used to administer LY3375880 or Buffer Matrix
Covance Clinical Research Inc
Daytona Beach, Florida, United States
Covance
Dallas, Texas, United States
Visual Analog Scale (VAS) Pain Score
The pain VAS is a participant administered single item scale designed to measure pain using a 0-100 millimeter (mm) horizontal VAS. Overall severity of participant's pain is indicated by placing a single mark on the scale from 0 mm (no pain) to 100 mm (severe pain).
Time frame: Part A: Within 1-minute post injection
Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY3375880
PK: Cmax of LY3375880
Time frame: Part B: Predose through Day 85
PK: Area Under the Concentration Versus Time Curve (AUC) of LY3375880
PK: AUC of LY3375880
Time frame: Part B: Predose through Day 85
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Manual syringe used to inject LY3375880