TReAtmeNt of Small Coronary Vessels: MagicTouch Sirolimus Coated Balloon

Inclusion Criteria: 1. Male or female patients ≥18 years 2. Patient with chronic stable angina or stabilized acute coronary syndromes with normal cardiac biomarker values Note: For patients showing elevated Troponin (e.g. non-STEMI patients) at baseline (within 72h pre-PCI) an additional blood sample must be collected prior to randomization to confirm that: * hs-cTn or Troponin I or T levels are stable, i.e. the value should be within 20% range of the value found in the first sample at baseline, or have dropped * CK-MB and CK levels are within normal range If hs-cTn or Troponin I or T levels are stable or have dropped, the CK-MB and CK levels are within normal ranges, and the ECG is normal, the patient may be included in the study. 3. The patient has a planned intervention in one or two separate major epicardial territories (LAD, LCX or RCA) and has at least one de-novo lesion in a small vessel (≤2.75mm by QCA prior to pre-dilatation) 4. Target lesion length ≤30 mm 5. Able to understand and provide informed consent and comply with all study procedures including 6 months angiographic follow-up 6. Patient must have completed the follow-up phase of any previous study Exclusion Criteria: 1. Patient is a woman who is pregnant or nursing (a pregnancy test must be performed within 7 days prior to the index procedure in women of child-bearing potential) 2. Evidence of ongoing acute myocardial infarction (AMI) in ECG and/or elevated cardiac biomarkers (according to local standard hospital practice) have not returned within normal limits at the time of procedure 3. Known contraindication or hypersensitivity to sirolimus, paclitaxel, or to medications such as aspirin, heparin, and all of the following four medications: clopidogrel bisulfate, ticlopidine, prasugrel, ticagrelor 4. Patient suffered from stroke/TIA during the last 6 months 5. LVEF \<30% 6. Platelet count \<100,000 cells/mm3 or \>400,000 cells/mm3, a WBC of \<3,000 cells/mm3, or documented or suspected liver disease (including laboratory evidence of hepatitis) 7. Known renal insufficiency (e.g. serum creatinine \>2.5mg/dL, or creatinine clearance ≤30 mL/min), or subject on dialysis, or acute kidney failure (as per physician judgment) 8. Patient undergoing planned surgery within 6 months with the necessity to stop DAPT 9. History of bleeding diathesis or coagulopathy 10. The patient is a recipient of a heart transplant 11. Concurrent medical condition with a life expectancy of less than 12 months 12. The patient is unwilling/not able to return for angiographic recatherisation at 6 month follow-up 13. Currently participating in another trial and not yet at its primary endpoint. Angiographic exclusion criteria: 14. The patient has a planned intervention in three separate major epicardial territories (3 vessel disease) 15. The patient has a planned intervention in the left-main plus two separate major epicardial territories (left-main plus 2 vessel disease) 16. Target vessel size \>2.75 mm (by QCA) 17. Target vessel size \<2.00 mm (by QCA) 18. Target lesion has a total occlusion or TIMI flow \<2 19. Target lesion in left main stem 20. The target vessel contains visible thrombus 21. Aorto-ostial target lesion (within 3 mm of the aorta junction) 22. Moderate-severe tortuous, calcified or angulated coronary anatomy of the target vessel that in the opinion of the investigator would result in suboptimal imaging or excessive risk of complication from placement of an OCT catheter 23. Lesion is located within an arterial or saphenous vein graft or distal to a diseased arterial or saphenous vein graft.