The aim of the study is to prospectively assess the role of mpMRI as a non invasive method for assessment of possible residual tumor after initial resection of non muscle invasive bladder tumor.
Comprehensive multiparametric (mp) MRI which includes T2 weighted imaging, dynamic contrast enhanced (DCE) imaging and DWI, was proven to be efficient tool in differentiating benign and malignant bladder lesion. morphological characterization of malignant bladder lesion (mapping/size/morphology/stalk), T stage differentiation and histological grade discrimination. The application of mpMRI in NMIBC with its added value as non invasive tool for initial staging and after primary resection could be a new helpful method for better diagnosis, risk categorization, refining the indications of second resection and proper determination of adjuvant treatment.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
100
all eligible patients will undergo mpMRI 4 weks after initial TURBT
after mpMRI all patients will subjected to second look TURBT
Urology and Nephrology Center
Al Mansurah, DK, Egypt
RECRUITINGassessment of the performance of mpMRI as a diagnostic tool for possible residual malignancy after initial TURBT
assessment of the performance of mpMRI as a diagnostic tool for possible residual malignancy after initial TURBT by comparing the results obtained by pre-second look TURBT mpMRI (Test of the study) with results of second look biopsy whether benign or malignant (Standard test).
Time frame: 1 year
Predictive capability of initial mpMRI of differentiation between benign and malignant bladder lesions.
Predictive capability of initial mpMRI of differentiation between benign and malignant bladder lesions.
Time frame: 1 year
2- Predictive capability of initial mpMRI of differentiation between NMIBC and muscle invasive disease.
2- Predictive capability of initial mpMRI of differentiation between NMIBC and muscle invasive disease.
Time frame: 1 year
Accuracy of bladder mapping in initial mpMRI (18) as a guide during TURBT.
Accuracy of bladder mapping in initial mpMRI (18) as a guide during TURBT.
Time frame: 1 year
Predictive value of initial mpMRI for characterization of NMIBC (T stage, Grading, Risk categorization).
Predictive value of initial mpMRI for characterization of NMIBC (T stage, Grading, Risk categorization).
Time frame: 1 year
Rate of over staging and under staging of NMIBC after second look TURBT in this prospective series.
Rate of over staging and under staging of NMIBC after second look TURBT in this prospective series.
Time frame: 1 year
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Morbidity (using modified Dindo-Clavian system for post-operative complications (19) and mortality rates after second look TURBT.
Morbidity (using modified Dindo-Clavian system for post-operative complications (19) and mortality rates after second look TURBT.
Time frame: 1 year
Readmission rate after second look TURBT.
Readmission rate after second look TURBT.
Time frame: 1 year
Cost comparison of mpMRI and second look TURBT.
Cost comparison of mpMRI and second look TURBT.
Time frame: 1 year