The Membrane Adsorbing OXiris Filter in Septic Patients With AKI

FRANCO TURANI100 enrolled

Overview

Patients with Sepsis / Septic Shock and AKI are submitted to Continuous Renal Replacement Therapy with the oXiris filter . The pro- inflammatory mediators , the endotoxin , interleukin 10 , the main cardiorespiratory indices and renal parameters are evaluated at the entry of the study and at the end of the treatment.

Patients with a diagnosis of sepsis or septic shock Gram + , Gram - and acute renal failure All patients are submitted to Continuous Renal Replacement Therapy with the treated heparin-coated membrane (oXiris;Baxter ); * Citrate Anticoagulation or Heparin with thromboelasthograpy monitoring . * Hemodynamic monitoring with dynamic parameters ( Cardiac Index ,Stroke Volume Variation , Pulse Pressure Variation ) and Echocardiography * Indirect Calorimetry ( before Continuous Renal Replacement Therapy and after 1 hour stopping Continuous Renal Replacement Therapy ) * Laboratory: white blood cell, creatinine, procalcitonin, Interleukin -6, Interleukin -10, Endotoxin , Lactate, diuresis, tromboelastography (post filter and arterial sample ) and dosage of Plasminogen Activator Inhibitor -1 at the same sites.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Sepsis Acute Renal Failure

Interventions

oXiris filterDEVICE

Continuous Renal Replacement Therapy with oXiris filter

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria:- Age \<18 years 75 years \> * Diagnosis of sepsis or septic shock (Sepsis III) * Mechanical Ventilation or non Invasive ventilation with PaO2 /FIO2 \< 200. * Renal failure ( AKI ≥ 1) * Endotoxin ( EAA ) : EAA ≥ 0.6 -0.9 \> or IL6 \> 150 pg/mL Exclusion Criteria: * Pregnancy; * Age \< 18 years 75\> * Chronic Renal failure or previous CRRT * Immunological disease or immunosuppressive drugs or EAA \< 0.6 with IL 6 in the normal range. * CGS \< 8 due to hemorrhagic or ischemic event. * ECMO v-v or a-v or ECCO2 removal. * No resolution of the surgical source of infection * Terminal condition * Any contraindication to heparin and other anticoagulant. * Other pathological conditions in which the oXiris filter is not indicated and other therapeutic options are required. (eg . Hepatic failure , Cardiac failure )

Locations (1)

Franco Turani

Rome, RM, Italy

RECRUITING