Predicting the risk of allergenic sensitizations and asthma development in the first year of life is difficult. Investigator decided to follow prospectively two cohorts of infants with acute bronchiolitis, hospitalized or treated at home, from the epidemic seasons of 2011-2012 and 2015-2017 to know their respiratory evolution, especially if they developed allergen sensitization and / or asthma.
Follow-up consultation 6 years after an episode of acute bronchiolitis at Clermont-Ferrand hospital with: * Consultation with a pneumopediatrician: collection of respiratory symptoms, respiratory treatments, evaluation of the atopic site and environmental risk factors for bronchial aggression, especially passive smoking; * Physical examination ; * Evaluation of precariousness during the same interview with the EPICES questionnaire; * Prick tests with positive control (histamine) and negative (physiological saline) and prick for the main pneumallergens (mites, alternaria, grasses, cat and dog) and trophallergens (egg, milk, fish, soy, wheat, peanut); * Blood test with blood count, determination of specific IgE (5 pneumallergens and 5 trophallergens), dosage of sRAGE; * Fonctionnal respiratory test with reversibility test
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
320
Consultation with a pneumopediatrician: collection of respiratory symptoms, respiratory treatments, evaluation of the atopic site and environmental risk factors for bronchial aggression, especially passive smoking
Chu Clermont-Ferrand
Clermont-Ferrand, France
Risk factors for asthma 6 years after an episode of acute bronchiolitis
Presence / absence of asthma 6-9 years after an episode of bronchiolitis during the first year of life The diagnosis of asthma is established during a consultation by a pneumopediatrician on the following criteria: * ≥3 documented respiratory symptoms ≥ 2 times; * Or an episode lasting ≥ 4 weeks; * With symptoms: tachypnea, wheezing, expiratory stridor, signs of chest retraction or wheezing diagnosed by a doctor.
Time frame: at 6 years
Correlation between onset of asthma and severity of bronchiolitis
Severity of acute bronchiolitis, assessed by a clinical score based on control signs, spO2 and respiratory rate (Wainwright score) and the length of hospital stay
Time frame: at 6 years
relationship between KL-6 serum markers and the occurrence of longer-term asthma
Correlation between onset of asthma and concentration of KL-6 during bronchiolitis
Time frame: at 6 years
relationship between CC16 serum markers and the occurrence of longer-term asthma
Correlation between onset of asthma and concentration of CC16 during bronchiolitis.
Time frame: at 6 years
relationship between sRAGE serum markers and the occurrence of longer-term asthma
Correlation between onset of asthma and concentration of sRAGE during bronchiolitis
Time frame: at 6 years
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