Single Nucleotide Polymorphisms (SNPs) Associated With Postoperative Analgesic Failure

Second Affiliated Hospital, School of Medicine, Zhejiang University198 enrolled

Overview

Postoperative pain remains relatively high within 48h for Chinese patients who receive video-assisted thoracoscopic surgery. Different patients experience different pain intensity. This suggests that there may be genetic variants that make some patients susceptible to analgesic failure. Using blood samples from patients, the investigators are going to analyze the relationship between single nucleotide polymorphisms (SNPs) in genes that are known to be involved in analgesic failure.

Study Type

OBSERVATIONAL

Enrollment

198

Conditions

Pain, Postoperative Thoracic Surgery, Video-Assisted Polymorphism, Single Nucleotide

Interventions

Genetic analysisGENETIC

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≤ 70 and Age ≥18 * Selective operation lung section with video-assisted thoracic surgery (VATS) * III ≥ American Society of Anesthesiologists classification (ASA classification) ≥I * Patients informed and agreed to join the study Exclusion Criteria: * Abnormal function of liver and kidney * Allergic- dependence history of alcohol, opioids and Local anesthetics * No noncompliance * Mental disease history，language communication disorder，cicatricial diathesis * Underweight or overweight（BMI\<18 or \>30) * Patients not suitable for clinical subjects for other reasons * Sedatives, analgesics, antiemetic drugs and anti pruritus drugs were used within 24hours before the operation. * History of previous abnormal anaesthesia * Women during pregnancy or lactation

Outcomes

Primary Outcomes

Postoperative analgesic failure

Once patient experience at least one of the following situations: 1. Bad patients sleep quality 2. Require extra analgesic drug 3. Low satisfaction with pain control 4. Bolus times \> 1 per hour

Time frame: 8 a.m. at the first day after surgery.