Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization.
Non-user or chronic electronic cigarette (EC) users will use an EC or control on three occasions:1) EC with nicotine, 2) EC without nicotine, 3) empty EC (control). Chronic tobacco cigarette (TC) smokers will use a TC or control on three occasions: 1) TC with nicotine (subject's own brand), 2) research TC with very low nicotine, 3) straw (control). The electrocardiogram will be recorded before and after acute exposures and analyzed for parameters representative of ventricular repolarization.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
110
Use an EC with nicotine for up to 30 minutes
Use an EC without nicotine for up to 30 minutes
sham control
UCaliforniaLA
Los Angeles, California, United States
Tpe
interval indicative of ventricular repolarization measured on ECG
Time frame: Change in Tpe 5 minutes before and 5 minutes after cigarette use
Tpe/QT
ratio of intervals indicative of ventricular repolarization measured on ECG
Time frame: Change in Tpe/QT 5 minutes before and 5 minutes after cigarette use
Tpe/QTc
ratio of intervals indicative of ventricular repolarization measured on ECG
Time frame: Change in Tpe/QTc 5 minutes before and 5 minutes after cigarette use
QT
interval indicative of ventricular repolarization measured on ECG
Time frame: Change in QT 5 minutes before and 5 minutes after cigarette use
QTc
interval indicative of ventricular repolarization measured on ECG
Time frame: Change in QTc 5 minutes before and 5 minutes after cigarette use
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smoke a TC
smoke a research TC with very low level nicotine