This is a Phase 1, randomized, open label, 2 way crossover drug drug interaction (DDI) study which will evaluate the impact of PF 06835919 on midazolam pharmacokinetics in healthy participants. Participants will be randomized to 1 of 2 treatment sequences as described below. A total of approximately 10 healthy male and/or female participants will be enrolled in this study so that approximately 5 participants will be enrolled into each treatment sequence. In this crossover study, 2 treatments are being assessed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
10
300 mg
7.5 mg
Brussels Clinical Research Unit
Brussels, Be-bru, Belgium
AUCinf of midazolam following a single oral dose
Area Under the Curve From Time Zero to Extrapolated Infinite Time (AUCinf)
Time frame: Baseline up to 51 days
AUClast of midazolam following a single oral dose.
Area Under the Curve From Time Zero to Last Quantifiable Concentration (AUClast)
Time frame: Baseline up to 51 days
Cmax of midazolam following a single oral dose.
Maximum Observed Plasma Concentration (Cmax)
Time frame: Baseline up to 51 days
Incidence of Adverse Events in participants
Time frame: Screening up to 79 days
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