To quantify the glycemic index of the SP energy-smart-based nutrition supplement and the SP Glucose-support formula as compared to a glucose drink. We hypothesized that both the energy-smart-based nutritional supplement and the SP Glucose-support formula will have low glycemic index. The aim of the study is to quantify the glycemic index of the SP energy-smart-based nutrition supplement and the SP Glucose-support formula as compared to a glucose drink. We hypothesized that both the energy-smart-based nutritional supplement and the SP Glucose-support formula will have low glycemic index.
Subjects: 9 non-diabetic (HbA1c \< 6.5) males aged 30-55 years with body mass indices ranging from 27.5 to 35 kg∙m-2. Individuals with impaired glucose tolerance will be included as long as they are not diagnosed with diabetes and their HbA1c is less than 6.5. Preliminary Testing: Medical history, weight, height, body composition via dual x-ray absorptiometry (DXA) and glycosylated hemoglobin (HbA1c) measurement. Protocol: After a 10-hour overnight fast, subjects will complete 3 experimental visits in which they will ingest one of three beverages in a randomized order. During experimental visits subjects will either be given the following 3 experimental drinks: * Full SP-glucose balance formula (200 kcal) * Energy smart carbohydrate blend (50 g, 200 kcal) * Liquid dextrose solution in the form of TRUTOL ® Glucose Tolerance Test Beverage (50 g, 200 kcal)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
15
Meal replacement drink containing 200 kcal
Carbohydrate blend drink designed for low glycemic responses containing 200 kcal
Liquid Dextrose drink of 200 kcal
Arizona Biomedical Collaborative
Phoenix, Arizona, United States
Area Under the Curve of Glucose
Positive integer of the area under the Curve of glucose
Time frame: 120 minutes
Area Under the Curve for Insulin
Positive integer of the area under the Curve of insulin
Time frame: 120 minutes
Blood glucose
Blood glucose levels
Time frame: 30, 60 and 120 minutes of the glucose challenge
Blood insulin
Blood insulin levels
Time frame: 30, 60 and 120 minutes of the glucose challenge
c-peptide
Blood levels of c-peptide
Time frame: 30, 60, and 120 minutes of the glucose challenge
glucagon
Blood levels of glucagon
Time frame: 30, 60, and 120 minutes of of the glucose challenge
Leptin
Blood levels of leptin
Time frame: 30, 60, and 120 minutes of the glucose challenge
Adiponectin
Blood levels of adiponectin
Time frame: 30, 60, and 120 minutes of the glucose challenge
glucagon-like-peptide-1
Blood levels of glucagon-like-peptide-1
Time frame: 30, 60, and 120 minutes of the glucose challenge
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