Randomized Clinical Trial following the evaluation of the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery.
Randomized Clinical Trial to evaluate the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery. Secondary Endpoint: Among secondary endpoints we will evaluate clinical variables such emergence and recovery characteristics (time to extubation and time to emergence-open eyes and response to verbal command), the need for postoperative mechanical ventilation, the post-anesthesia recovery score and ICU length of stay.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
80
administration of sevoflurane
administration of Desflurane
Hospital general universitario Gregorio Marañón
Madrid, Spain
Change in Biochemical parameters
NGAL in urine
Time frame: All these parameters will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
Cystatin C(mg/L) in plasma
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
Creatinine(mg/dL) in plasma
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
sodium(mMol/L) in plasma
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
potassium(mMol/L) in plasma
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
Chloride(mMol/L) in plasma
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
albumin(g/dL) in plasma
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
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osmolarity(mOsm/Kg) in plasma
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
NGAL in plasma
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
Creatinine(mg/dL) in urine
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
sodium(mMol/L) in urine
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
potassium(mMol/L) in urine
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
Chloride(mMol/L) in urine
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
albumin(g/dL) in urine
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Change in Biochemical parameters
osmolarity(mOsm/Kg) in urine
Time frame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Need for postoperative mechanical ventilation
hours of mechanical ventilation in ICU
Time frame: 24 hours
ICU length of stay
hours in ICU
Time frame: up to 24 hours
anesthetic recovery
time to extubation(minutes).
Time frame: These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded at baseline and after surgery. time frame upto 1 hour(stimated)
anesthetic recovery
time to spontaneous eye opening(minutes)
Time frame: These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded after surgery. timeframe up to 1 hour(stimated).
anesthetic recovery
time until first response to verbal commands(minutes)
Time frame: These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded after surgery. timeframe up to 1 hour(stimated).
anesthetic recovery
The post-anesthesia recovery score ( Modified Aldrete score) (0-1-2 from worse to better)
Time frame: These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded at baseline and after surgery. timeframe 1 hour(stimated)