Peri-implantitis is an inflammatory disease that leads to loss of jawbone around dental implants. Recent discoveries have identified increased release of Titanium (Ti) particles around implants as being associated to peri-implantitis. In this ancillary study to the Dental Hygiene and Peri-Implant Tissues Homeostasis trial the objective is to determine potential triggers of increased Ti dissolution from the implant surface and the mechanisms by which Ti dissolution products amplify peri-implant inflammation. Results from this study will determine whether there is a differential response to Ti particles across individuals, which may alter susceptibility to peri-implantitis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SCREENING
Masking
DOUBLE
Enrollment
34
Mechanical cleaning of titanium implants, peri-implantitis debridement.
Titanium scalers and nylon brushed used for implant cleaning
UTHealth San Antonio
San Antonio, Texas, United States
University of Washington School of Dentistry
Seattle, Washington, United States
Titanium Dissolution
The primary outcome of the clinical trial will be titanium dissolution in periimplant plaque following treatment quantified using inductively coupled mass spectrometry (ICMS)
Time frame: 12 weeks +/- 4 weeks
Expression of pro-inflammatory cytokines in response to titanium
We will determine whether PBMCs from peri-implantitis persons and controls have a differential pro-inflammatory response to titanium particles.
Time frame: baseline
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