Spatial Analysis of the Intestinal Microbiota in Healthy Subjects

Inclusion Criteria: 1. Signed informed consent 2. Age: 18-65 years Exclusion Criteria: 1. Known organic gastrointestinal disease (e.g. inflammatory bowel disease, irritable bowel syndrome, chronic diarrhoea or constipation) 2. History of or present gastrointestinal malignancy or polyposis 3. Recent (gastrointestinal) infection (within last 6 months) 4. History of major gastrointestinal surgery (e.g. gastric bypass) 5. Eosinophilic disorders of the gastrointestinal tract 6. Current communicable disease (e.g. upper respiratory tract infection) 7. Malignant disease and/or patients who are receiving systemic anti-neoplastic agents 8. Psychiatric diseases (e.g. dementia, depression, schizophrenia, autism, Asperger Syndrome) or other incapacity for adequate cooperation 9. Chronic neurological/neurodegenerative diseases (e.g. Parkinson's disease, multiple sclerosis) 10. Autoimmune disease and/or patients receiving immunosuppressive medications 11. Major relevant allergies (e.g. food allergy, multiple allergies) 12. Chronic pain syndromes (e.g. fibromyalgia) 13. Chronic fatigue syndrome 14. Obesity (body mass index\>30) or metabolic syndrome 15. Antimicrobial treatment or prophylaxis within the last 3 months 16. Other chronic use of drugs that may affect the microbiome, e.g. proton pump inhibitors 17. Females who are pregnant or breast-feeding 18. Known clinically significant abnormal laboratory values 19. Abuse of alcohol or drugs 20. Probiotic intake within the last 6 weeks 21. Bowel cleansing within the last 6 months 22. Any clinically significant disease/condition which in the investigator's opinion could interfere with the results of the trial