This study was aimed to reveal the clinical features,natural history of the diseases and current therapeutic situations of cerebral venous thrombosis (CVT) in China mainland. Blood samples and cerebrospinal fluid samples will be collected after recruitment to reveal the pathological mechanisms of CVT and identify the biomarkers for CVT.
cerebral venous thrombosis (CVT) is caused by a clot in the cerebral vein, which resulted in an obstruction of the blood outflow. CVT mainly includes cerebral venous sinus thrombosis, deep cerebral vein thrombosis and cortical vein thrombosis. However, the epidemiological features of CVT in China mainland remained obscure. This study was aimed to establish a multicenter cohort recruiting patients with CVT across 31 provinces and municipalities in China mainland. Clinical features,natural history of the diseases and current therapeutic situations will be analyzed to reveal the epidemiological features of CVT. Blood samples and cerebrospinal fluid samples will be collected after recruitment to reveal the pathological mechanisms of CVT and identify the biomarkers for CVT. Patients will be followed-up at 1, 3, 6, 12 months from baseline to evaluate the clinical prognosis and therapeutic outcomes.
Study Type
OBSERVATIONAL
Enrollment
3,000
Death rate
A combination of death form of all causes
Time frame: 1 year from baseline
Functional independence
Defined as modified Rankin score (0-5) equal to or lower than 2
Time frame: 1 year from baseline
Recurrence of cerebral venous sinus thrombosis, deep cerebral venous thrombosis and cortical vein thrombosis
Diagnosed by DSA, MRV, CTV or HR-MRI
Time frame: 1 year from baseline
Incidence of hemorrhagic complication
Extracranial hemorrhage (fall in hemoglobin of 2 gram/dl or more within 48 hours) or intracranial hemorrhage
Time frame: 1 year from baseline
Incidence of sinus wall rupture
Time frame: 1 year from baseline
Incidence of acute ischemic stroke
Time frame: 1 year from baseline
Incidence of acute myocardial infarction
Time frame: 1 year from baseline
Incidence of pulmonary embolism
Time frame: 1 year from baseline
Incidence of deep venous thrombosis
Time frame: 1 year from baseline
Incidence of epilepsy
Time frame: 1 year from baseline
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Incidence of allergic reaction
Time frame: 1 year from baseline