Colorectal Metastasis Prevention International Trial 2

Inclusion Criteria: 1\. Patients planned for surgery for primary resection of colon or rectal cancer with curative intent. 2. Single colonic or rectal carcinoma, proven by full colonoscopy and tumor biopsy. 3. No evidence of metastatic disease prior to surgery. Minimal workup would include abdominal CT with IV contrast (or CT+liver US) and chest XR. 4. ASA score of 1-3 or ECOG Performance Status of 0 to 1 5. Signed informed consent form 6. Willing and able to comply with study procedures (physically and mentally) 7. Men and women from age 20 to age 80 \- Exclusion Criteria: 1. Patients with metastatic disease, known prior to surgery 2. Patients in whom surgical resection is planned without curative intent 3. Patients with renal failure, measured by creatinine level \>1.5 4. Patients with significant heart failure (NYHA functional class 3 or higher) 5. Patients with significant liver failure (known cirrhosis, Bilirubin level\>2) 6. Patients currently suffering from asthma or Chronic Obstructive Pulmonary Disease (COPD) 7. Patients treated pharmacologically for diabetes mellitus (type 1/2), 8. Patients with peripheral vascular disease 9. Patients with known allergy to one or more of the study medications. 10. Patients with known allergy to any medication from the non-steroidal anti- inflammatory drug group or beta-blockers family 11. Patients treated chronically with any type of a beta-adrenergic blocker or a COX inhibitor 12. Patients with bradycardia or second or third degree AV block 13. Patients with a history of CVA/TIA 14. Patients with Printzmetal's angina 15. Patients with right sided heart failure owing to pulmonary hypertension 16. Patients with significant diagnosed cardiomegaly 17. Patients with (current) pheochromocytoma 18. Patients with chronic Digoxin treatment 19. Patients with active peptic disease 20. Pregnant women 21. Patients who participate in another interventional study 22. Patients with history or concomitant malignant disease of any type (except for the current colon/rectal cancer) 23. Patients who were treated with chemotherapy in the last 10 years for any reason besides neo-adjuvant therapy for rectal cancer within the last six months. 24. Patients who are treated with immunosuppressive medications 25. Patients with Immunodeficiency Disorders, or autoimmune disease treated by immunosuppressive medications. 26. Patients suffering from sick sinus syndrome