The aim of this observational study is to evaluate the prevalence of uncomplicated pregnancies in women suffering from congenital fibrinogen disorders (i.e, hypofibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia) as well as to describe pregnancies outcomes in such diseases.
Women with quantitative or qualitative fibrinogen disorders are often more prone to obstetrical complications, from bleeding to recurrent miscarriages or thrombosis. Data on fibrinogen levels variations throughout the pregnancy and on the delivery management are lacking. In this observational study will be include adult women with pas obstetrical history. A general questionnaire on demographics and clinical data will be filled out by the patient's physician. A detailed questionnaire on obstetrical data will also be completed contacting the patient in case of lacking data.
Study Type
OBSERVATIONAL
Enrollment
149
Hopital Port-Royal
Paris, France
Jessenius Faculty of Medicine and University Hospital
Martin, Slovakia
University Hospitals of Geneva
Geneva, Switzerland
Prevalence of normal issue pregnancy
All pregnancy not resulting in miscarriage, stillbirth or abortion
Time frame: At inclusion
Prevalence of pregnancy without complications
All pregnancy not resulting in intrauterine growth retardation, preterm labor, pregnancy-induced hypertension, gestational diabetes, preeclampsia, abruption placenta, anamniota, vaginal bleeding requiring medical intervention
Time frame: At inclusion
Modalities of delivery
Vaginal versus caesarean cut
Time frame: At inclusion
Modalities of delivery
Instrumental delivery vs none
Time frame: At inclusion
Post-partum complications
Post-partum haemorrhage and/or thrombotic event within 3 months after the delivery
Time frame: At inclusion
Fibrinogen variations
Fibrinogen levels throughout the pregnancy
Time frame: At inclusion
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