Introduction: Pityriasis lichenoides (PL) is an inflammatory dermatitis of undetermined origin consisting of specific papular lesions reflecting an "indolent" lymphoproliferative state. The current classification is confusing because it mixes semiological and chronological notions. The objectives of this study are to better describe the clinical, epidemiological, histological, phenotypic and evolutionary aspects of PL in an adult population. Methods: Investigators will perform a retrospective cohort study including patients with clinical and histological diagnosis of PL from the coding of the Department of Pathology of Henri-Mondor Hospital and from medical records and photographs of lesions if available, between January 2012 and August 2018. A follow-up telephone interviews will also be proposed to each patient to collect evolution data. Photographs will be systematically reviewed as well as cutaneous samples and a genomic analysis will be performed. Conclusion: Investigators would like to better understand clinical, histological features and evolutionary aspects of PL in an adult population.
Study Type
OBSERVATIONAL
Enrollment
52
To study clinical Aspects of Pityriasis Lichenoides on a large series of adult patients
Epidemiological and and clinical aspect description of the lesions from medical charts and photographs: age, sex, suspected trigger of the disease, past medical history, frequency of necrotic lesions, topography of lesions, fever, altered general conditions, treatment modalities of the flare.
Time frame: It will be measured within 6 months of enrollment
To study histological features of Pityriasis Lichenoides
The histological description will make use of a centralized re-reading of the slides according to a standardized grid (appearance of the epidermis, type and topography of the dermal infiltrate, results of the immunolabelings etc ...). The investigators aim to investigate the frequency of patients with patterns of pityriasis lichenoides mimicking lymphomatoid papulosis or mycosis fungoides and to correlate the histological aspect with clinical lesions.
Time frame: It will be measured within 6 months of enrollment
To study molecular features of Pityriasis Lichenoides
number of clone T in the skin and in the blood.
Time frame: It will be measured within 6 months of enrollment
To study the treatment during patients' monitoring
number of patients with need of a prolonged treatment
Time frame: It will be measured within 6 months of enrollment
To study the duration of outbreak during patients' monitoring
the time to healing
Time frame: It will be measured within 6 months of enrollment
To study the relapse during patients' monitoring
the number of relapses
Time frame: It will be measured within 6 months of enrollment
To study the number of outbreaks during patients' monitoring
the number of outbreaks
Time frame: It will be measured within 6 months of enrollment
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