Retrospective Non-interventional Analysis of Opportunistic Infections in Immunocompromised and Frail Patients

N/AUnknownNCT03920735

University Hospital, Strasbourg, France1,000 enrolled

Overview

The analysis of a cohort of consecutive non-selected patients from the Strasbourg University Hospital, and therefore representative of the real life, will allow better identifying the risk factors for these infections (by comparison with a cohort of patient with similar conditions of immunosuppression and no infection) and improving the diagnosis and therapeutic management. The primary objective is to identify prognosis factors affecting survival in patients with opportunistic infections

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Hematologic Disease Neoplams Transplantation Immunologic Deficiency Syndromes Critical Illness

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion criteria: * Non selected consecutive immunocompromised or frail patients with an opportunistic infection * Hospitalized in any of the department of the University Hospital of Strasbourg * For epidemiological study, patients with similar immunodepression of frail condition and no opportunistic infection Exclusion criteria: \- Opposition of the patient to use his personal data

Outcomes

Primary Outcomes

Short- and long-term survival, overall and in specific subgroups of patients

Time frame: Long-term time point : 1st may 2019

Short- and long-term survival, overall and in specific subgroups of patients

Time frame: Short term : 1 month

Short- and long-term survival, overall and in specific subgroups of patients

Time frame: Short term : 3 months

Short- and long-term survival, overall and in specific subgroups of patients

Time frame: Short term : 6 months

Secondary Outcomes

Risk factors predisposing to opportunistic infections - age - gender - Type of work - Location - Tobacco use

Time frame: first day of opportunistic infection

Prognosis factors in patients with opportunistic infection affecting the response to antimicrobial therapy (using response criteria defined by EORTC/MSG)

Time frame: first day of opportunistic infection

Identification of baseline prognosis factors affecting the 3 months survival

Time frame: first day of opportunistic infection

Identification of baseline prognosis factors affecting the 6 months survival

Time frame: first day of opportunistic infection

Incidence of specific opportunistic infections in different host groups

Time frame: evolution of a 20-year-period

Description of imaging patterns opportunistic infections: analysis of chest CT-scan and cerebral CT-scan and MRI by radiologists

Time frame: at first day of infection and up to 12 weeks

Assessment of performance of Aspergillus galactomannan detection test in serum

Time frame: at onset and up to 1 week

Assessment of performance of Aspergillus galactomannan detection test in bronchoalveolar lavage

Time frame: at onset and up to 1 week

Response rate

Time frame: at 1, 3 and 6 months

Retrospective Non-interventional Analysis of Opportunistic Infections in Immunocompromised and Frail Patients

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts