To evaluate the effect of systemic administration of zinc on the gingival crevicular fluid level of total oxidant capacity in controlled Type-2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal therapy.
Hypozincaemia and hyperzincuria is known to be present in patients with type-2 diabetes, and Zinc supplementation is known to be helpful in restoring plasma Zinc levels to normal,Zinc's deficiency can lead to an increase in circulating glucose due to beta cells malfunctioning and resistance to insulin, which makes it easier for type 2 diabetes mellitus (DM2) to happen ,Zinc was found to be a structural part of key anti-oxidant enzymes such as superoxide dismutase (SOD), and Zinc deficiency impaired their synthesis, leading to increased oxidative stress
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
34
systemic administration of Zinc sulfate with scaling and root planing
scaling and root planing
change from baseline Hb-A1c
Time frame: change from baseline Hb-A1c at 3 monthes
Hb-A1c
Hb-A1c
Time frame: at the baseline and after 3 months
Probing pocket depth
Probing pocket depth Measured as the distance between the gingival margin and the apical part of the pocket will be measured using William's graduated periodontal probe.
Time frame: at the baseline and after 3 months
Clinical attachment level
It will be measured from the cemento-enamel junction till the apical part of the pocket.
Time frame: at the baseline and after 3 months
Gingival index
Gingival Index for a specific tooth == Average (points for the 4 surfaces)
Time frame: at the baseline and after 3 months
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