This study is aimed to determine effect of paraprobiotic Lactobacillus plantarum IS-10506 on humoral immune response by measuring faecal sIgA and blood IgG, IgM, and IgA
The type of the study is double blind randomize placebo-controlled trial with minimum 72 subjects which divided into 2 groups i.e. 1) placebo group which will receive UHT milk (125 mL) and 2) treatment group which will received UHT milk + paraprobiotic Lactobacillus plantarum IS-10506 5 x 1010 CFU/day (125 mL). The subjects have to consume one pack of milk every day for 90 consecutive days. Before and after intervention (day 30 and day 90), several data will be collected i.e. faecal sIgA, blood IgG, IgM, and IgA. The subjects recruited from elementary school in Yogyakarta District.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
79
125 ml UHT milk (+Lactobacillus plantarum IS-10506) given to treatment group
125 ml UHT milk given to placebo group
Universitas Gadjah Mada
Sleman, D.I.Yogyakarta, Indonesia
Serum IgG
Measuring IgG (ng/mL) in collected serum
Time frame: 90 days
Serum IgA
Measuring IgA (ng/mL) in collected serum
Time frame: 90 days
Serum IgM
Measuring IgM (ng/mL) in collected serum
Time frame: 90 days
Faecal sIgA
Measuring sIgA (ng/mL) in collected feses
Time frame: 90 days
Weight
Measuring weight (kg) change
Time frame: 90 days
Height
Measuring height (cm) change
Time frame: 90 days
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