The investigators will conduct a 2-arm randomized controlled pilot, feasibility feeding study in which 28 participants will be randomized to receive either a calorie-restricted Dietary Approaches to Stop Hypertension (DASH) diet or a calorie-restricted standard American diet provided by the study for 4 weeks. Participants will be non-Hispanic black or white, generally healthy females (14 black, 14 white). The investigators will collect fecal samples at multiple time points before, during, and after the dietary intervention to analyze for changes in the gut microbiota and functional-level metabolic products. This work will be led by an interdisciplinary team including expertise in bio-behavioral science, microbiology, nutrition science, bioinformatics, and biostatistics all with cross-cutting expertise in health disparities, prevention research, nutrition, the gut microbiota, inflammation and other biomarkers. The rationale for the proposed research is that once the interactions between race, diet, and the gut microbiota are more fully understood, targeted diet modifications may provide new and innovative approaches for the prevention and treatment of obesity and obesity-related diseases.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
28
brief description
describe
Moffit Cancer Center
Tampa, Florida, United States
Mean Weight Change of Participants
Weight change as measured by a scale in kilograms at multiple time points will be calculated and averaged.
Time frame: Baseline to day 28
Mean Weight Change of Participants
Weight change as measured by a scale in kilograms at multiple time points will be calculated and averaged.
Time frame: Day 28 to Day 42
Mean Weight Change of Participants
Weight change as measured by a scale in kilograms at multiple time points will be calculated and averaged.
Time frame: Baseline to day 42
Diet-specific changes in secondary bile acid
The investigators will calculate changes in cholic acid in milligrams.
Time frame: Baseline to day 28
Diet-specific changes in secondary bile acid
The investigators will calculate changes in cholic acid in milligrams.
Time frame: day 28 to day 42
Diet-specific changes in secondary bile acid
The investigators will calculate changes in cholic acid in milligrams.
Time frame: baseline to day 42
Diet-specific changes in inflammatory marker
The investigators will calculate changes in c-reactive protein in mg/L.
Time frame: baseline to day 28
Diet-specific changes in inflammatory marker
The investigators will calculate changes in c-reactive protein in mg/L.
Time frame: day 28 to day 42
Diet-specific changes in inflammatory marker
The investigators will calculate changes in c-reactive protein in mg/L.
Time frame: baseline to day 42
Diet-specific changes in short chain fatty acids
The investigators will calculate changes in acetic acid in mmol/L
Time frame: baseline to day 28
Diet-specific changes in short chain fatty acids
The investigators will calculate changes in acetic acid in mmol/L
Time frame: day 28 to day 42
Diet-specific changes in short chain fatty acids
The investigators will calculate changes in acetic acid in mmol/L
Time frame: baseline to day 42
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