Prevention of Sepsis-related Organ Dysfunction With Allocetra-OTS

Inclusion Criteria: * Suspected, presumed or documented infection from any source. * Initiation of antibiotics. * Meets Sepsis 3 criteria: The presence of organ dysfunction as identified by a total SOFA score ≥ 2 points above baseline. * Adult male or female, age between 18 and 85. * GCS of \>13 with verbal score of 5. * Signed written informed consent by the patient. Exclusion Criteria: * Participation in an interventional investigational trial within 30 days prior to diagnosis of sepsis. * Significant trauma requiring hospitalization within 30 days prior to diagnosis of sepsis. * Surgical intervention or hospitalization within 45 days prior to diagnosis of sepsis. * Pregnancy or breast-feeding female. * Progressive or poorly-controlled malignancies or \< 6 month after active treatment for cancer (chemotherapy or irradiation). * Terminally ill patients defined as patients that prior to the current hospitalization are expected to live \< 6 months (as assessed by the physician responsible for the patient). * Known active acute or chronic viral infections, e.g. Hepatitis B Virus (HBV) or Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV) or other chronic infection. * Known severe chronic respiratory health problems with severe pulmonary hypertension (≥40 mmHg) or respirator dependency. * Known active upper gastrointestinal (GI) tract ulceration or hepatic dysfunction including but not limited to: biopsy-proven cirrhosis; portal hypertension; episodes of past upper GI bleeding attributed to portal hypertension; or prior episodes of hepatic failure, encephalopathy, or coma. * Known New York Heart Association (NYHA) class IV heart failure or unstable angina, ventricular arrhythmias, active ischemic heart disease, or myocardial infarction within six months prior to diagnosis of sepsis. * Known immunocompromised state or medications known to be immunosuppressive. * Organ allograft or previous history of stem cell transplantation