KN046 in Subjects With Late Stage Esophageal Squamous Cell Carcinoma

Inclusion Criteria: * Signed informed consent form; * 18 years of age or older, Male or female, * Pathologically confirmed diagnosis of esophageal squamous cell carcinoma (ESCC) * Had failed at front line regimen containing fluorouracil, paclitaxel and platinum. Disease progression within 6 months from previous adjuvant chemotherapy will be considered as failure of first line systemic therapy; * Baseline measurable disease according to RECIST 1.1 from irradiated region or progressed within a previous radiation field; * ECOG performance status of 0 or 1; * Have provided tumor tissue from locations not previously irradiated. Tumor biopsy may be from either the primary or metastatic site of disease; * Adequate organ function assessed within 7 days prior to first trial treatment: * Have a life expectancy of at least 3 months; * If female of childbearing potential, have a negative serum pregnancy test within 7 days prior to first trial treatment; * If female of childbearing potential or a male subject with a partner with childbearing potential, be willing to use a highly effective method of contraception (with a failure rate of less than 1.0% per year) from first study treatment to 24 weeks after completion of the trial treatment; Exclusion Criteria: * Untreated active CNS metastasis or leptomeningeal metastasis. Subjects may be eligible provided they are treated and clinically stable for at least 4 weeks and have no evidence of new or enlarging brain metastases and also are off steroids 7 days for treating brain metastasis prior to first trial treatment; * Is currently participating and receiving an investigational drug or has participated in a study of an investigational drug within 4 weeks prior to the first dose of trial treatment; * Has received other anti-tumor treatment, including traditional Chinese medicine which has approved anti-tumor indication within 4 weeks prior to the first trial treatment; * Major surgery for any reason, except diagnostic biopsy, within 4 weeks of the first administration of trial treatment and/or if the subject has not fully recovered from the surgery within 4 weeks of the first administration of trial treatment; * Curative radiation within 3 months of the first dose of trial treatment. Radiation to more than 30% of the bone marrow or with a wide field of radiation should not be used within 4 weeks prior to the first administration of trial treatment; * Subjects receiving immunosuppressive agents (such as steroids) for any reason should be tapered off these drugs before initiation of trial treatment (with the exception of subjects with adrenal insufficiency, who may continue corticosteroids at physiologic replacement doses, equivalent to \< 10 mg prednisone daily, inhaled steroids and topical use of steroids); * Vaccination within 28 days of the first administration of trial treatment, except for administration of inactivated vaccines (e.g., inactivated influenza vaccines); * Has interstitial lung disease, or a history of pneumonitis that required oral or intravenous glucocorticoids to assist with management;